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! colspan="7" style="background-color: #004089;" | {{Tnavbar-header|'''Buffalo Bills roster'''|Buffalo Bills roster|plain=1|fontcolor=white}}
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| style="font-size: 95%;" valign="top" | '''Quarterbacks'''
*  5 [[Trent Edwards]]
* 10 [[Gibran Hamdan]]
*  7 [[J. P. Losman]]

'''Running Backs'''
* 36 [[Darian Barnes]] FB
* 22 [[Fred Jackson (American football)|Fred Jackson]]
* 23 [[Marshawn Lynch]]
* 25 ''[[Xavier Omon]]''

'''Wide Receivers'''
* 83 [[Lee Evans (American football)|Lee Evans]]
* 81 ''[[James Hardy (American football)|James Hardy]]''
* 17 [[Justin Jenkins (American football)|Justin Jenkins]]
* 13 ''[[Steve Johnson (American football)|Steve Johnson]]''
* 11 [[Roscoe Parrish]] PR
* 82 [[Josh Reed]]

'''Tight Ends'''
* 86 ''[[Derek Fine]]''
* 84 [[Robert Royal]]
* 80 [[Derek Schouman]] FB
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| style="font-size: 95%;" valign="top" | '''Offensive Linemen'''
* 77 ''[[Demetrius Bell]]'' T
* 60 [[Brad Butler]] G
* 73 [[Kirk Chambers]] T
* 66 [[Derrick Dockery]] G
* 67 [[Melvin Fowler]] C
* 70 [[Matt Murphy (American football)|Matt Murphy]] T/TE
* 75 [[Duke Preston]] G/C
* 68 [[Langston Walker]] T
* 65 [[Jason Whittle]] G/C

'''Defensive Linemen'''
* 96 [[Copeland Bryan]] DE
* 92 [[Ryan Denney]] DE
* 93 ''[[Chris Ellis (American football)|Chris Ellis]]'' DE
* 91 [[Spencer Johnson (American football)|Spencer Johnson]] DT
* 90 [[Chris Kelsay]] DE
* 97 [[John McCargo]] DT
* 94 [[Aaron Schobel]] DE
* 99 [[Marcus Stroud]] DT
* 95 [[Kyle Williams (defensive tackle)|Kyle Williams]] DT
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| style="font-size: 95%;" valign="top" | '''Linebackers'''
* 57 [[Jon Corto]] OLB
* 55 [[Angelo Crowell]] OLB
* 52 [[John DiGiorgio]] ILB
* 56 [[Keith Ellison (American football)|Keith Ellison]] OLB
* 59 [[Kawika Mitchell]] OLB
* 51 [[Paul Posluszny]] ILB

'''Defensive Backs'''
* 27 ''[[Reggie Corner]]'' CB
* 33 [[Jabari Greer]] CB
* 24 [[Terrence McGee]] CB/KR
* 28 ''[[Leodis McKelvin]]'' CB
* 43 [[Bryan Scott]] S
* 30 [[Ko Simpson]] FS
* 29 [[John Wendling]] SS
* 37 [[George Wilson (American football)|George Wilson]] S
* 20 [[Donte Whitner]] SS
* 26 [[Ashton Youboty]] CB

'''Special Teams'''
*  9 [[Rian Lindell]] K
*  8 [[Brian Moorman]] P
* 72 [[Ryan Neill]] LS/DE
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| style="font-size: 95%;" valign="top" | '''Reserve Lists'''
* 16 [[Matt Baker (American football)|Matt Baker]] QB (IR) [[Image:Injury icon.svg|7px]]
* 50 ''[[Alvin Bowen]]'' OLB (IR) [[Image:Injury icon.svg|7px]]
* 71 [[Jason Peters]] OT (Did Not Report)

'''Practice Squad'''
* 53 ''[[Marcus Buggs]]'' OLB
* 76 ''[[Dustin Dickinson]]'' OT
* 42 ''[[Bruce Hall (American football)|Bruce Hall]]'' RB
* 18 ''[[C. J. Hawthorne]]'' WR
* 14 [[Felton Huggins]] WR
* 74 [[Corey Mace]] DE/DT
* -- ''[[Jonathan Stupar]]'' TE

''Rookies in italics'' 
[http://buffalobills.com/team/roster.html Roster] updated [[2008-09-01]] 
[http://www.buffalobills.com/depth_chart/index.html Depth Chart] • [http://www.buffalobills.com/team/Transactions.html Transactions] 
53 Active, 3 Inactive, 7 PS

→ [[List of current National Football League team rosters|More rosters]]
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