Difference between revisions of "Template:Absolute activities of tibolone and metabolites"
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| − | |+ class="nowrap" | {{Navbar|Absolute activities of tibolone and metabolites|mini=y}} Absolute activities (nM) of | + | |+ class="nowrap" | {{Navbar|Absolute activities of tibolone and metabolites|mini=y}} Absolute activities (nM) of <noinclude>[[tibolone]]</noinclude><includeonly>tibolone</includeonly> and metabolites |
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! Compound !! Code name !! {{abbrlink|PR|Progesterone receptor}} !! {{abbrlink|AR|Androgen receptor}} !! {{abbrlink|ERα|Estrogen receptor alpha}} !! {{abbrlink|ERβ|Estrogen receptor beta}} !! {{abbrlink|GR|Glucocorticoid receptor}} !! {{abbrlink|MR|Mineralocorticoid receptor}} | ! Compound !! Code name !! {{abbrlink|PR|Progesterone receptor}} !! {{abbrlink|AR|Androgen receptor}} !! {{abbrlink|ERα|Estrogen receptor alpha}} !! {{abbrlink|ERβ|Estrogen receptor beta}} !! {{abbrlink|GR|Glucocorticoid receptor}} !! {{abbrlink|MR|Mineralocorticoid receptor}} | ||
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| {{No selflink|3β-Hydroxytibolone}} || ORG-30126 || ''20000''* || ''{{abbr|ND|No data}}''* || 2.4 || 115 || ''{{abbr|ND|No data}}''* || ''3310''* | | {{No selflink|3β-Hydroxytibolone}} || ORG-30126 || ''20000''* || ''{{abbr|ND|No data}}''* || 2.4 || 115 || ''{{abbr|ND|No data}}''* || ''3310''* | ||
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| − | | colspan="8" style="width: 1px; background-color:#eaecf0; text-align: center;" | '''Notes:''' Values are affinities (nM). Non-italicized values are {{abbrlink|EC<sub>50</sub>|half-maximal effective concentration}}. Italicized values with an asterisk (*) are {{abbrlink|IC<sub>50</sub>|half-maximal inhibitory concentration}}. Reference [[ligand (biochemistry)|ligand]]s (EC<sub>50</sub>) were [[promegestone]] (5 nM for PR), [[metribolone]] (0.1 nM for AR), [[estradiol (medication)|estradiol]] (0.018 nM for ERα, 0.08 nM for ERβ), [[dexamethasone]] (6 nM for GR), and [[aldosterone]] (0.36 nM for MR). '''Sources:''' <noinclude><ref name=" | + | | colspan="8" style="width: 1px; background-color:#eaecf0; text-align: center;" | '''Notes:''' Values are affinities (nM). Non-italicized values are {{abbrlink|EC<sub>50</sub>|half-maximal effective concentration}}. Italicized values with an asterisk (*) are {{abbrlink|IC<sub>50</sub>|half-maximal inhibitory concentration}}. Reference [[ligand (biochemistry)|ligand]]s (EC<sub>50</sub>) were [[promegestone]] (5 nM for PR), [[metribolone]] (0.1 nM for AR), [[estradiol (medication)|estradiol]] (0.018 nM for ERα, 0.08 nM for ERβ), [[dexamethasone]] (6 nM for GR), and [[aldosterone]] (0.36 nM for MR). '''Sources:''' <noinclude><ref name="pmid19464167">{{cite journal | vauthors = Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T | title = Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites | journal = J. Steroid Biochem. Mol. Biol. | volume = 116 | issue = 1-2 | pages = 8–14 | date = August 2009 | pmid = 19464167 | doi = 10.1016/j.jsbmb.2009.03.008 | url = }}</ref></noinclude><includeonly>See template.</includeonly> |
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Latest revision as of 15:41, 16 October 2020
| Compound | Code name | PR | AR | ERα | ERβ | GR | MR |
|---|---|---|---|---|---|---|---|
| Template:No selflink | ORG-OD-14 | 123 | 1.05 | 4 | 105 | 2410* | 170* |
| Template:No selflink | ORG-OM-38 | 46 | 0.2 | 26 | 300 | 1760* | 30* |
| Template:No selflink | ORG-4094 | 2400* | 135* | 1.7 | 100 | ND* | 1160* |
| Template:No selflink | ORG-30126 | 20000* | ND* | 2.4 | 115 | ND* | 3310* |
| Notes: Values are affinities (nM). Non-italicized values are EC50. Italicized values with an asterisk (*) are IC50. Reference ligands (EC50) were promegestone (5 nM for PR), metribolone (0.1 nM for AR), estradiol (0.018 nM for ERα, 0.08 nM for ERβ), dexamethasone (6 nM for GR), and aldosterone (0.36 nM for MR). Sources: [1] | |||||||
References
- ↑ Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T (August 2009). "Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites". J. Steroid Biochem. Mol. Biol. 116 (1–2): 8–14. doi:10.1016/j.jsbmb.2009.03.008. PMID 19464167.
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