Difference between revisions of "Template:Amino acid metabolism enzymes"

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{{Navbox
 
{{Navbox
| name = Amino acid metabolism enzymes
+
| name = Amino acid metabolism enzymes
| title = [[Metabolism]]: [[amino acid metabolism]]{{·}} [[Amino acid synthesis|synthesis]] and catabolism [[enzyme]]s ([[Essential amino acid|essential]] in CAPS)
+
| title = [[Metabolism]]: [[Protein metabolism]], [[Amino acid synthesis|synthesis]] and catabolism [[enzyme]]s
| style =  
+
| state = {{{state|}}}
| titlestyle = background:#e7dcc3
+
| listclass = hlist
| groupstyle = background-color: AntiqueWhite
 
  
| group1 = [[Ketogenic amino acid|K]]→[[acetyl-CoA]]
+
| above= ''[[Essential amino acid]]s are in Capitals''
|  list1 = {{Navbox subgroup
 
  | groupstyle = background-color: AntiqueWhite
 
  
  | group1 = [[lysine|LYSINE]]→
+
| group1 = [[Ketogenic amino acid|K]]→[[acetyl-CoA]]
  | list1 = [[Saccharopine dehydrogenase]]{{·}} [[Glutaryl-CoA dehydrogenase]]
+
| list1 = {{Navbox|child
  
  | group2 = [[leucine|LEUCINE]]→
+
  | group1 = [[lysine|LYSINE]]→
  | list2 = [[Branched chain aminotransferase]]{{·}} [[Branched-chain alpha-keto acid dehydrogenase complex]]{{·}} [[Isovaleryl coenzyme A dehydrogenase]]{{·}} [[Methylcrotonyl-CoA carboxylase]]{{·}} [[Methylglutaconyl-CoA hydratase]]{{·}} [[3-hydroxy-3-methylglutaryl-CoA lyase]]
+
  | list1 =
 +
* [[Saccharopine dehydrogenase]]
 +
* [[Glutaryl-CoA dehydrogenase]]
  
  | group3 = [[tryptophan|TRYPTOPHAN]]→
+
  | group2 = [[leucine|LEUCINE]]→
  | list3 = [[Indoleamine 2,3-dioxygenase]]/[[Tryptophan 2,3-dioxygenase]]{{·}} [[Arylformamidase]]{{·}} [[Kynureninase]]{{·}} [[3-hydroxyanthranilate oxidase]]{{·}} [[Aminocarboxymuconate-semialdehyde decarboxylase]]{{·}} [[Aminomuconate-semialdehyde dehydrogenase]]
+
  | list2 =
 +
* [[3-Hydroxybutyryl-CoA dehydrogenase]]
 +
* [[Branched-chain amino acid aminotransferase]]
 +
* [[Branched-chain alpha-keto acid dehydrogenase complex]]
 +
* [[Enoyl-CoA hydratase]]
 +
* [[3-hydroxy-3-methylglutaryl-CoA lyase|HMG-CoA lyase]]
 +
* [[HMG-CoA reductase]]
 +
* [[Isovaleryl coenzyme A dehydrogenase]]
 +
* [[α-ketoisocaproate dioxygenase|α-Ketoisocaproate dioxygenase]]
 +
* [[Leucine 2,3-aminomutase]]
 +
* [[Methylcrotonyl-CoA carboxylase]]
 +
* [[Methylglutaconyl-CoA hydratase]]
 +
(See [[Template:Leucine metabolism in humans]] – this diagram does not include the pathway for β-leucine synthesis via leucine 2,3-aminomutase)
  
  | group4 = [[phenylalanine|PHENYLALANINE]]→[[tyrosine]]
+
  | group3 = [[tryptophan|TRYPTOPHAN]]→
  |  list4 = (see below)
+
  | list3 =
 +
* [[Indoleamine 2,3-dioxygenase]]/[[Tryptophan 2,3-dioxygenase]]
 +
* [[Arylformamidase]]
 +
* [[Kynureninase]]
 +
* [[3-hydroxyanthranilate oxidase]]
 +
* [[Aminocarboxymuconate-semialdehyde decarboxylase]]
 +
* [[Aminomuconate-semialdehyde dehydrogenase]]
  
}}
+
  | group4 = [[phenylalanine|PHENYLALANINE]]→[[tyrosine]]→
 +
  | list4 =
 +
* (see below)
  
| group2 = [[Glucogenic amino acid|G]]
+
  }}
| list2 = {{Navbox subgroup
 
| groupstyle = background-color: AntiqueWhite
 
  
| group1 = G→[[pyruvate]]<BR>→[[citrate]]
+
| group2 = [[Glucogenic amino acid|G]]
| list1  = {{Navbox subgroup
+
| list2 = {{Navbox|child
  | groupstyle = background-color: AntiqueWhite
 
  
  | group1 = [[glycine]]→[[serine]]
+
  | group1 = G→[[pyruvate]]<br />→[[citrate]]
  | list1 = [[Serine hydroxymethyltransferase]]{{·}} [[Serine dehydratase]]<BR>
+
  | list1 = {{Navbox|child
  
[[glycine]]→[[creatine]]: [[Guanidinoacetate N-methyltransferase]]{{·}} [[Creatine kinase]]
+
    | group1 = [[glycine]]→[[serine]]
 +
    | list1 =
 +
* [[Serine hydroxymethyltransferase]]
 +
* [[Serine dehydratase]]
  
  | group2 = [[alanine]]→
+
* [[glycine]]→[[creatine]]: [[Guanidinoacetate N-methyltransferase]]
  |  list2 = [[Alanine transaminase]]
+
* [[Creatine kinase]]
  
  | group3 = [[cysteine]]→
+
    | group2 = [[alanine]]→
  | list3 = [[D-cysteine desulfhydrase]]
+
    | list2 =
 +
* [[Alanine transaminase]]
  
  | group4 = [[threonine]]→
+
    | group3 = [[cysteine]]→
  | list4 = [[L-threonine dehydrogenase]]
+
    | list3 =
 +
* [[D-cysteine desulfhydrase]]
  
}}
+
    | group4 = [[threonine]]→
 +
    | list4 =
 +
* [[L-threonine dehydrogenase]]
  
| group3 = G→[[glutamate]]→<BR>[[alpha-Ketoglutaric acid|α-ketoglutarate]]
+
  }}
|  list3 = {{Navbox subgroup
 
  | groupstyle = background-color: AntiqueWhite
 
  
 +
  | group3 = G→[[glutamate]]→<br />[[alpha-Ketoglutaric acid|α-ketoglutarate]]
 +
  | list3 = {{Navbox|child
  
  | group5 = [[histidine|HISTIDINE]]→
+
    | group5 = [[histidine|HISTIDINE]]→
  | list5 = [[Histidine ammonia-lyase]]{{·}} [[Urocanase|Urocanate hydratase]]{{·}} [[Formiminotransferase cyclodeaminase]]
+
    | list5 =
 +
* [[Histidine ammonia-lyase]]
 +
* [[Urocanase|Urocanate hydratase]]
 +
* [[Formiminotransferase cyclodeaminase]]
  
  | group6 = [[proline]]→
+
    | group6 = [[proline]]→
  | list6 = [[Proline oxidase]]{{·}} [[Pyrroline-5-carboxylate reductase]]{{·}} [[1-Pyrroline-5-carboxylate dehydrogenase]]/[[Aldehyde dehydrogenase 4 family, member A1|ALDH4A1]]{{·}} [[PYCR1]]
+
    | list6 =
 +
* [[Proline oxidase]]
 +
* [[Pyrroline-5-carboxylate reductase]]
 +
* [[1-Pyrroline-5-carboxylate dehydrogenase]]/[[Aldehyde dehydrogenase 4 family, member A1|ALDH4A1]]
 +
* [[PYCR1]]
  
  | group7 = [[arginine]]→
+
    | group7 = [[arginine]]→
  | list7 = [[Ornithine aminotransferase]]{{·}} [[Ornithine decarboxylase]]{{·}} [[Agmatinase]]
+
    | list7 =
 +
* [[Ornithine aminotransferase]]
 +
* [[Ornithine decarboxylase]]
 +
* [[Agmatinase]]
  
  | group8 = →[[alpha-ketoglutarate]]→TCA
+
    | group8 = →[[alpha-ketoglutarate]]→TCA
  | list8 = [[Glutamate dehydrogenase]]
+
    | list8 =
 +
* [[Glutamate dehydrogenase]]
  
 +
    | group9 = Other
 +
    | list9 =
 +
* [[cysteine]]+[[glutamate]]→[[glutathione]]: [[Gamma-glutamylcysteine synthetase]]
 +
* [[Glutathione synthetase]]
 +
* [[Gamma-glutamyl transpeptidase]]
  
  | group9 = Other
+
* [[glutamate]]→[[glutamine]]: [[Glutamine synthetase]]
  |  list9 = [[cysteine]]+[[glutamate]]→[[glutathione]]: [[Gamma-glutamylcysteine synthetase]]{{·}} [[Glutathione synthetase]]{{·}} [[Gamma-glutamyl transpeptidase]]<BR>
+
* [[Glutaminase]]
  
[[glutamate]]→[[glutamine]]: [[Glutamine synthetase]]{{·}} [[Glutaminase]]
+
  }}
  
}}
+
  | group4 = G→[[propionyl-CoA]]→<br />[[succinyl-CoA]]
 +
  | list4 = {{Navbox|child
  
| group4 = G→[[propionyl-CoA]]→<BR>[[succinyl-CoA]]
+
    | group1 = [[valine|VALINE]]→
|  list4 = {{Navbox subgroup
+
    | list1 =
  | groupstyle = background-color: AntiqueWhite
+
* [[Branched-chain amino acid aminotransferase]]
 +
* [[Branched-chain alpha-keto acid dehydrogenase complex]]
 +
* [[Enoyl-CoA hydratase]]
 +
* [[3-hydroxyisobutyryl-CoA hydrolase]]
 +
* [[3-hydroxyisobutyrate dehydrogenase]]
 +
* [[Methylmalonate-semialdehyde dehydrogenase (acylating)|Methylmalonate semialdehyde dehydrogenase]]
  
  | group1 = [[valine|VALINE]]→
+
    | group2 = [[isoleucine|ISOLEUCINE]]→
  | list1 = [[Branched chain aminotransferase]]{{·}} [[Branched-chain alpha-keto acid dehydrogenase complex]]{{·}} [[Enoyl-CoA hydratase]]{{·}} [[3-hydroxyisobutyryl-CoA hydrolase]]{{·}} [[3-hydroxyisobutyrate dehydrogenase]]{{·}} [[Methylmalonate-semialdehyde dehydrogenase (acylating)|Methylmalonate semialdehyde dehydrogenase]]
+
    | list2 =
 +
* [[Branched-chain amino acid aminotransferase]]
 +
* [[Branched-chain alpha-keto acid dehydrogenase complex]]
 +
* [[3-hydroxy-2-methylbutyryl-CoA dehydrogenase]]
  
  | group2 = [[isoleucine|ISOLEUCINE]]→
+
    | group3 = [[methionine|METHIONINE]]→
  | list2 = [[Branched chain aminotransferase]]{{·}} [[Branched-chain alpha-keto acid dehydrogenase complex]]{{·}} [[3-hydroxy-2-methylbutyryl-CoA dehydrogenase]]
+
    | list3 =
 +
* ''[[Methionine#Generation of homocysteine|generation of homocysteine]]:'' [[Methionine adenosyltransferase]]
 +
* [[Adenosylhomocysteinase]]
  
  | group3 = [[methionine|METHIONINE]]→
+
* ''[[Methionine#Regeneration of methionine|regeneration of methionine]]:'' [[Methionine synthase]]/[[methionine synthase|Homocysteine methyltransferase]]
  |  list3 = ''[[Methionine#Generation_of_homocysteine|generation of homocysteine]]:'' [[Methionine adenosyltransferase]]{{·}} [[Adenosylhomocysteinase]]
+
* [[Betaine-homocysteine S-methyltransferase|Betaine-homocysteine methyltransferase]]
  
''[[Methionine#Regeneration_of_methionine|regeneration of methionine]]:'' [[Methionine synthase]]/[[methionine synthase|Homocysteine methyltransferase]]{{·}} [[Betaine-homocysteine S-methyltransferase|Betaine-homocysteine methyltransferase]]
+
* ''[[Methionine#Conversion to cysteine|conversion to cysteine]]:'' [[Cystathionine beta synthase]]
 +
* [[Cystathionine gamma-lyase]]
  
''[[Methionine#Conversion_to_cysteine|conversion to cysteine]]:'' [[Cystathionine beta synthase]]{{·}} [[Cystathionine gamma-lyase]]
+
    | group4 = [[threonine|THREONINE]]
 +
    | list4 =
 +
* [[Threonine aldolase]]
  
  | group4 = [[threonine|THREONINE]]
+
    | group5 = [[succinyl-CoA]]→TCA
  | list4 = [[Threonine aldolase]]
+
    | list5 =
 +
* [[Propionyl-CoA carboxylase]]
 +
* [[Methylmalonyl CoA epimerase]]
 +
* [[Methylmalonyl-CoA mutase]]
  
  | group5 = →[[succinyl-CoA]]→TCA
+
  }}
  |  list5 = [[Propionyl-CoA carboxylase]]{{·}} [[Methylmalonyl CoA epimerase]]{{·}} [[Methylmalonyl-CoA mutase]]
 
  
}}
+
  | group5 = G→[[fumarate]]
 +
  | list5 = {{Navbox|child
  
| group5 = G→[[fumarate]]
+
    | group13 = [[phenylalanine|PHENYLALANINE]]→[[tyrosine]]
| list5 = {{Navbox subgroup
+
    | list13 =
  | groupstyle = background-color: AntiqueWhite
+
* [[Phenylalanine hydroxylase]]
 +
* [[Tyrosine aminotransferase]]
 +
* [[4-Hydroxyphenylpyruvate dioxygenase]]
 +
* [[Homogentisate 1,2-dioxygenase]]
 +
* [[Fumarylacetoacetate hydrolase]]
  
  | group13 = [[phenylalanine|PHENYLALANINE]]→[[tyrosine]]→
+
* [[tyrosine]]→[[melanin]]: [[Tyrosinase]]
  |  list13 = [[Phenylalanine hydroxylase]]{{·}} [[Tyrosine aminotransferase]]{{·}} [[4-Hydroxyphenylpyruvate dioxygenase]]{{·}} [[Homogentisate 1,2-dioxygenase]]{{·}} [[Fumarylacetoacetate hydrolase]]<BR>
 
  
[[tyrosine]]→[[melanin]]: [[Tyrosinase]]
+
  }}
  
}}
+
  | group6 = G→[[Oxaloacetic acid|oxaloacetate]]
 +
  | list6 = {{Navbox|child
  
| group6 = G→[[Oxaloacetic acid|oxaloacetate]]
+
    | group14 = [[asparagine]]→[[aspartate]]→
|  list6 = {{Navbox subgroup
+
    | list14 =
  | groupstyle = background-color: AntiqueWhite
+
* [[Asparaginase]]/[[Asparagine synthetase]]
  | group14 = [[asparagine]]→[[aspartate]]→
+
* [[Aspartate transaminase]]
  | list14 = [[Asparaginase]]/[[Asparagine synthetase]]{{·}} [[Aspartate transaminase]]
 
  
}}
+
  }}
 
+
}}
}}
 
 
 
| below = {{Metabolic navs}}
 
  
 
}}<noinclude>
 
}}<noinclude>
 
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{{collapsible option}}
[[Category:Amino acid metabolic pathway templates|{{PAGENAME}}]]
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[[Category:Amino acid metabolic pathway templates]]
[[zh:模板:氨基酸代谢酶类]]
 
 
</noinclude>
 
</noinclude>

Latest revision as of 15:13, 20 October 2020

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