Difference between revisions of "Template:GABA receptor modulators"
Jump to navigation
Jump to search
imported>Medgirl131 |
imported>Dr Curious m |
||
| (58 intermediate revisions by 15 users not shown) | |||
| Line 1: | Line 1: | ||
{{Navbox | {{Navbox | ||
| − | | name = | + | | name = GABA receptor modulators |
| − | | title = [[GABA]] | + | | title = [[GABA receptor|{{abbr|GABA|γ-Aminobutyric acid}} receptor]] [[receptor modulator|modulator]]s |
| state = {{{state<includeonly>|collapsed</includeonly>}}} | | state = {{{state<includeonly>|collapsed</includeonly>}}} | ||
| − | | | + | | bodyclass = hlist |
| groupstyle = text-align:center; | | groupstyle = text-align:center; | ||
| − | | group1 = [[ | + | | group1 = [[Ionotropic GABA receptors|Ionotropic]] |
| − | | list1 = {{Navbox subgroup | + | | list1 = {{Navbox|subgroup |
| + | | groupstyle = text-align:center | ||
| + | | groupwidth = 5em | ||
| − | | group1 = | + | | group1 = {{abbrlink|GABA<sub>A</sub>|γ-Aminobutyric acid A receptor}} |
| − | | list1 = | + | | list1 = |
| − | * | + | * ''Agonists:'' [[Catechin|(+)-Catechin]]<!--α4βδ--> |
* [[Bamaluzole]] | * [[Bamaluzole]] | ||
* [[Barbiturate]]s (e.g., [[phenobarbital]])<!--At high concentrations--> | * [[Barbiturate]]s (e.g., [[phenobarbital]])<!--At high concentrations--> | ||
| + | * [[Beta-Alanine]] | ||
* [[BL-1020]] | * [[BL-1020]] | ||
* [[5-Aminovaleric acid|DAVA]] | * [[5-Aminovaleric acid|DAVA]] | ||
| Line 29: | Line 32: | ||
* [[Isonipecotic acid]] | * [[Isonipecotic acid]] | ||
* [[Kojic amine]] | * [[Kojic amine]] | ||
| + | * [[L-838,417]] | ||
* [[Lignan]]s (e.g., [[honokiol]]) | * [[Lignan]]s (e.g., [[honokiol]]) | ||
| + | * [[Methylglyoxal]] | ||
* [[Monastrol]]<!--α4βδ--> | * [[Monastrol]]<!--α4βδ--> | ||
* [[Muscimol]] | * [[Muscimol]] | ||
| + | * [[Nefiracetam]] | ||
* [[Neuroactive steroid]]s (e.g., [[allopregnanolone]])<!--At high concentrations--> | * [[Neuroactive steroid]]s (e.g., [[allopregnanolone]])<!--At high concentrations--> | ||
* [[Org 20599]] | * [[Org 20599]] | ||
| + | * [[PF-6372865]] | ||
| + | * [[Phenibut]] | ||
* [[Picamilon]] | * [[Picamilon]] | ||
* [[Piperidine-4-sulfonic acid|P4S]] | * [[Piperidine-4-sulfonic acid|P4S]] | ||
| Line 40: | Line 48: | ||
* [[Quisqualamine]] | * [[Quisqualamine]] | ||
* [[SL-75102]] | * [[SL-75102]] | ||
| + | * [[Taurine]] | ||
* [[trans-4-Aminocrotonic acid|TACA]] | * [[trans-4-Aminocrotonic acid|TACA]] | ||
* [[trans-2-(Aminomethyl)cyclopropanecarboxylic acid|TAMP]] | * [[trans-2-(Aminomethyl)cyclopropanecarboxylic acid|TAMP]] | ||
| Line 47: | Line 56: | ||
* [[(Z)-3-((Aminoiminomethyl)thio)prop-2-enoic acid|ZAPA]] | * [[(Z)-3-((Aminoiminomethyl)thio)prop-2-enoic acid|ZAPA]] | ||
| − | * '' | + | * ''Positive modulators (abridged; see [[Template:GABAAR PAMs|here]] for a full list):'' [[α-Ethyl-α-methylthiobutyrolactone|α-EMTBL]] |
| − | * [[Alcohol]]s (e.g., [[ | + | * [[Alcohol]]s (e.g., [[alcohol (drug)|drinking alcohol]], [[tert-Amyl alcohol|2M2B]]) |
| + | * [[Anabolic steroid]]s | ||
* [[Avermectin]]s (e.g., [[ivermectin]]) | * [[Avermectin]]s (e.g., [[ivermectin]]) | ||
* [[Barbiturate]]s (e.g., [[phenobarbital]]) | * [[Barbiturate]]s (e.g., [[phenobarbital]]) | ||
| Line 70: | Line 80: | ||
* [[Loreclezole]] | * [[Loreclezole]] | ||
* [[Monastrol]] | * [[Monastrol]] | ||
| − | * [[Neuroactive steroid]]s (e.g., [[allopregnanolone]], [[cholesterol]]) | + | * [[Neuroactive steroid]]s (e.g., [[allopregnanolone]], [[cholesterol]], [[THDOC]]) |
* [[Niacin]] | * [[Niacin]] | ||
* [[Nicotinamide|Nicotinamide (niacinamide)]] | * [[Nicotinamide|Nicotinamide (niacinamide)]] | ||
| Line 91: | Line 101: | ||
* [[Volatility (chemistry)|Volatiles]]/[[gas]]es (e.g., [[chloral hydrate]], [[chloroform]], [[diethyl ether]], [[paraldehyde]], [[sevoflurane]]) | * [[Volatility (chemistry)|Volatiles]]/[[gas]]es (e.g., [[chloral hydrate]], [[chloroform]], [[diethyl ether]], [[paraldehyde]], [[sevoflurane]]) | ||
| − | * | + | * ''Antagonists:'' [[Bicuculline]] |
* [[Coriamyrtin]] | * [[Coriamyrtin]] | ||
* [[Dihydrosecurinine]] | * [[Dihydrosecurinine]] | ||
| Line 106: | Line 116: | ||
* [[Tutin (toxin)|Tutin]] | * [[Tutin (toxin)|Tutin]] | ||
| − | * '' | + | * ''Negative modulators:'' [[5-Ethyl-5-(1,3-dimethylbut-1'-enyl)barbituric acid|1,3M1B]] |
* [[5-Ethyl-5-(3-methylbut-2'-enyl)barbituric acid|3M2B]] | * [[5-Ethyl-5-(3-methylbut-2'-enyl)barbituric acid|3M2B]] | ||
| + | * [[11-Ketoprogesterone]] | ||
* [[17-Phenylandrostenol]] | * [[17-Phenylandrostenol]] | ||
* [[α5IA|α5IA (LS-193,268)]] | * [[α5IA|α5IA (LS-193,268)]] | ||
| Line 115: | Line 126: | ||
* [[Propyl β-carboline-3-carboxylate|β-CCP]] | * [[Propyl β-carboline-3-carboxylate|β-CCP]] | ||
* [[β-Ethyl-β-methyl-γ-butyrolactone|β-EMGBL]] | * [[β-Ethyl-β-methyl-γ-butyrolactone|β-EMGBL]] | ||
| + | * [[Anabolic steroid]]s | ||
* [[Amiloride]] | * [[Amiloride]] | ||
* [[Anisatin]] | * [[Anisatin]] | ||
| Line 120: | Line 132: | ||
* [[Basmisanil]] | * [[Basmisanil]] | ||
* [[Bemegride]] | * [[Bemegride]] | ||
| + | * [[Bicyclic phosphate]]s ([[TBPS]], [[TBPO]], [[IPTBO]]) | ||
| + | * [[BIDN]] | ||
* [[Bilobalide]] | * [[Bilobalide]] | ||
| + | * [[Bupropion]] | ||
* [[5-(2-Cyclohexylideneethyl)-5-ethylbarbituric acid|CHEB]] | * [[5-(2-Cyclohexylideneethyl)-5-ethylbarbituric acid|CHEB]] | ||
| + | * [[Chlorophenylsilatrane]] | ||
* [[Cicutoxin]] | * [[Cicutoxin]] | ||
* [[Cloflubicyne]] | * [[Cloflubicyne]] | ||
| Line 131: | Line 147: | ||
* [[DMCM]] | * [[DMCM]] | ||
* [[5,7-Dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one|DMPC]] | * [[5,7-Dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one|DMPC]] | ||
| − | * [[ | + | * [[EBOB]] |
* [[Etbicyphat]] | * [[Etbicyphat]] | ||
* [[FG-7142|FG-7142 (ZK-31906)]] | * [[FG-7142|FG-7142 (ZK-31906)]] | ||
| Line 140: | Line 156: | ||
* [[Flurothyl]] | * [[Flurothyl]] | ||
* [[Furosemide]] | * [[Furosemide]] | ||
| + | * [[Golexanolone]] | ||
* [[Iomazenil (123I)|Iomazenil (<sup>123</sup>I)]] | * [[Iomazenil (123I)|Iomazenil (<sup>123</sup>I)]] | ||
| + | * [[IPTBO]] | ||
* [[Isopregnanolone|Isopregnanolone (sepranolone)]] | * [[Isopregnanolone|Isopregnanolone (sepranolone)]] | ||
* [[L-655,708]] | * [[L-655,708]] | ||
| Line 153: | Line 171: | ||
* [[Naltrexone]] | * [[Naltrexone]] | ||
* [[Nicardipine]] | * [[Nicardipine]] | ||
| + | * [[Nonsteroidal antiandrogen]]s (e.g., [[apalutamide]], [[bicalutamide]], [[enzalutamide]], [[flutamide]], [[nilutamide]]) | ||
* [[Oenanthotoxin]] | * [[Oenanthotoxin]] | ||
| − | * [[ | + | * [[Pentylenetetrazol|Pentylenetetrazol (pentetrazol)]] |
* [[Phenylsilatrane]] | * [[Phenylsilatrane]] | ||
| − | * [[Picrotoxin]] (i.e., [[picrotin]] and [[ | + | * [[Picrotoxin]] (i.e., [[picrotin]], [[picrotoxinin]] and [[dihydropicrotoxinin]]) |
* [[Pregnenolone sulfate]] | * [[Pregnenolone sulfate]] | ||
* [[Propybicyphat]] | * [[Propybicyphat]] | ||
| Line 170: | Line 189: | ||
* [[TB-21007]] | * [[TB-21007]] | ||
* [[t-Butylbicycloorthobenzoate|TBOB]] | * [[t-Butylbicycloorthobenzoate|TBOB]] | ||
| − | * [[ | + | * [[TBPS]] |
* [[TCS-1105]] | * [[TCS-1105]] | ||
* [[Terbequinil]] | * [[Terbequinil]] | ||
| Line 179: | Line 198: | ||
* [[ZK-93426]] | * [[ZK-93426]] | ||
| − | | group2 = | + | | group2 = {{abbrlink|GABA<sub>A</sub>-ρ|γ-Aminobutyric acid A-rho receptor}} |
| − | | list2 = | + | | list2 = |
| − | * | + | * ''Agonists:'' [[BL-1020]] |
* [[(Z)-4-Amino-2-butenoic acid|CACA]] | * [[(Z)-4-Amino-2-butenoic acid|CACA]] | ||
* [[(+)-cis-2-Aminomethylcyclopropane carboxylic acid|CAMP]] | * [[(+)-cis-2-Aminomethylcyclopropane carboxylic acid|CAMP]] | ||
| Line 198: | Line 217: | ||
* [[Tolgabide]] | * [[Tolgabide]] | ||
| − | * '' | + | * ''Positive modulators:'' [[Allopregnanolone]] |
| + | * [[Alphaxolone]] | ||
| + | * [[Allotetrahydrodeoxycorticosterone|ATHDOC]] | ||
| + | * [[Lanthanide]]s | ||
| − | * | + | * ''Antagonists:'' [[(S)-4-Amino-2-methylbutanoic acid|(S)-2-MeGABA]] |
* [[(S)-(4-Aminocyclopent-1-enyl)butylphosphinic acid|(S)-4-ACPBPA]] | * [[(S)-(4-Aminocyclopent-1-enyl)butylphosphinic acid|(S)-4-ACPBPA]] | ||
* [[(S)-4-Aminocyclopent-1-ene-1-carboxylic acid|(S)-4-ACPCA]] | * [[(S)-4-Aminocyclopent-1-ene-1-carboxylic acid|(S)-4-ACPCA]] | ||
| Line 224: | Line 246: | ||
* [[(Z)-3-((Aminoiminomethyl)thio)prop-2-enoic acid|ZAPA]] | * [[(Z)-3-((Aminoiminomethyl)thio)prop-2-enoic acid|ZAPA]] | ||
| − | * '' | + | * ''Negative modulators:'' [[5α-Dihydroprogesterone]] |
| + | * [[Bilobalide]] | ||
| + | * [[Loreclezole]] | ||
* [[Picrotoxin]] ([[picrotin]], [[picrotoxinin]]) | * [[Picrotoxin]] ([[picrotin]], [[picrotoxinin]]) | ||
| + | * [[Pregnanolone]] | ||
* [[ROD-188]] | * [[ROD-188]] | ||
| + | * [[Tetrahydrodeoxycorticosterone|THDOC]] | ||
* [[Zinc]] | * [[Zinc]] | ||
| − | + | }} | |
| − | | | + | |
| − | * | + | | group2 = [[Metabotropic]] |
| + | | list2 = {{Navbox|subgroup | ||
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em | ||
| + | |||
| + | | group1 = {{abbrlink|GABA<sub>B</sub>|γ-Aminobutyric acid B receptor}} | ||
| + | | list1 = | ||
| + | * ''Agonists:'' [[1,4-Butanediol]] | ||
| + | * [[4-Fluorophenibut]] | ||
* [[Aceburic acid]] | * [[Aceburic acid]] | ||
* [[Arbaclofen]] | * [[Arbaclofen]] | ||
| Line 245: | Line 279: | ||
* [[gamma-Hydroxyvaleric acid|GHV]] | * [[gamma-Hydroxyvaleric acid|GHV]] | ||
* [[gamma-Valerolactone|GVL]] | * [[gamma-Valerolactone|GVL]] | ||
| + | * [[Isovaline]] | ||
* [[Lesogaberan]] | * [[Lesogaberan]] | ||
* [[Phenibut]] | * [[Phenibut]] | ||
| Line 253: | Line 288: | ||
* [[SL 75102]] | * [[SL 75102]] | ||
* [[Tolgabide]] | * [[Tolgabide]] | ||
| + | * [[Tolibut]] | ||
| − | * '' | + | * ''Positive modulators:'' [[ADX-71441]] |
* [[BHF-177]] | * [[BHF-177]] | ||
* [[BHFF]] | * [[BHFF]] | ||
| Line 262: | Line 298: | ||
* [[GS-39783]] | * [[GS-39783]] | ||
* [[rac-BHFF]] | * [[rac-BHFF]] | ||
| + | * [[KK-92A]] | ||
| − | * | + | * ''Antagonists:'' [[2-Hydroxysaclofen]] |
* [[CGP-35348]] | * [[CGP-35348]] | ||
* [[CGP-46381]] | * [[CGP-46381]] | ||
| Line 277: | Line 314: | ||
* [[SKF-97541]] | * [[SKF-97541]] | ||
| − | * '' | + | * ''Negative modulators:'' [[Compound 14]] |
}} | }} | ||
| − | | | + | | below = |
| − | + | ;See also | |
| − | + | : ''[[Template:Receptor modulators|Receptor/signaling modulators]] '' | |
| − | + | : ''[[Template:GABAA receptor positive modulators|GABA<sub>A</sub> receptor positive modulators]] '' | |
| − | + | : ''[[Template:GABA metabolism and transport modulators|GABA metabolism/transport modulators]] '' | |
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
}}<noinclude> | }}<noinclude> | ||
Latest revision as of 15:45, 6 March 2020
Initial visibility: currently defaults to autocollapse
To set this template's initial visibility, the |state= parameter may be used:
|state=collapsed:{{GABA receptor modulators|state=collapsed}}to show the template collapsed, i.e., hidden apart from its title bar|state=expanded:{{GABA receptor modulators|state=expanded}}to show the template expanded, i.e., fully visible|state=autocollapse:{{GABA receptor modulators|state=autocollapse}}
If the |state= parameter in the template on this page is not set, the template's initial visibility is taken from the |default= parameter in the Collapsible option template. For the template on this page, that currently evaluates to autocollapse.