Difference between revisions of "Template:GABA receptor modulators"

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{{Navbox
 
{{Navbox
| name  = GABAergics
+
| name  = GABA receptor modulators
| title = [[GABA]]ergics
+
| title = [[GABA receptor|{{abbr|GABA|γ-Aminobutyric acid}} receptor]] [[receptor modulator|modulator]]s
 
| state = {{{state<includeonly>|collapsed</includeonly>}}}
 
| state = {{{state<includeonly>|collapsed</includeonly>}}}
| listclass = hlist
+
| bodyclass = hlist
 
| groupstyle = text-align:center;
 
| groupstyle = text-align:center;
  
   | group1 = [[Receptor (biochemistry)|Receptor]]<br /><small>([[Ligand (biochemistry)|ligand]]s)</small>
+
   | group1 = [[Ionotropic GABA receptors|Ionotropic]]
   |  list1 = {{Navbox subgroup
+
   |  list1 = {{Navbox|subgroup
 +
  | groupstyle = text-align:center
 +
  | groupwidth = 5em
  
     | group1 = [[GABAA receptor|GABA<sub>A</sub>]]
+
     | group1 = {{abbrlink|GABA<sub>A</sub>|γ-Aminobutyric acid A receptor}}
     | list1  =
+
     | list1  =  
* '''Agonists:''' [[Catechin|(+)-Catechin]]<!--α4βδ-->
+
* ''Agonists:'' [[Catechin|(+)-Catechin]]<!--α4βδ-->
 
* [[Bamaluzole]]
 
* [[Bamaluzole]]
 
* [[Barbiturate]]s (e.g., [[phenobarbital]])<!--At high concentrations-->
 
* [[Barbiturate]]s (e.g., [[phenobarbital]])<!--At high concentrations-->
 +
* [[Beta-Alanine]]
 
* [[BL-1020]]
 
* [[BL-1020]]
 
* [[5-Aminovaleric acid|DAVA]]
 
* [[5-Aminovaleric acid|DAVA]]
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* [[Isonipecotic acid]]
 
* [[Isonipecotic acid]]
 
* [[Kojic amine]]
 
* [[Kojic amine]]
 +
* [[L-838,417]]
 
* [[Lignan]]s (e.g., [[honokiol]])
 
* [[Lignan]]s (e.g., [[honokiol]])
 +
* [[Methylglyoxal]]
 
* [[Monastrol]]<!--α4βδ-->
 
* [[Monastrol]]<!--α4βδ-->
 
* [[Muscimol]]
 
* [[Muscimol]]
 +
* [[Nefiracetam]]
 
* [[Neuroactive steroid]]s (e.g., [[allopregnanolone]])<!--At high concentrations-->
 
* [[Neuroactive steroid]]s (e.g., [[allopregnanolone]])<!--At high concentrations-->
 
* [[Org 20599]]
 
* [[Org 20599]]
 +
* [[PF-6372865]]
 +
* [[Phenibut]]
 
* [[Picamilon]]
 
* [[Picamilon]]
 
* [[Piperidine-4-sulfonic acid|P4S]]
 
* [[Piperidine-4-sulfonic acid|P4S]]
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* [[Quisqualamine]]
 
* [[Quisqualamine]]
 
* [[SL-75102]]
 
* [[SL-75102]]
 +
* [[Taurine]]
 
* [[trans-4-Aminocrotonic acid|TACA]]
 
* [[trans-4-Aminocrotonic acid|TACA]]
 
* [[trans-2-(Aminomethyl)cyclopropanecarboxylic acid|TAMP]]
 
* [[trans-2-(Aminomethyl)cyclopropanecarboxylic acid|TAMP]]
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* [[(Z)-3-((Aminoiminomethyl)thio)prop-2-enoic acid|ZAPA]]
 
* [[(Z)-3-((Aminoiminomethyl)thio)prop-2-enoic acid|ZAPA]]
  
* '''PAMs''' ''(abridged; see [[Template:GABAAergics|here]] for a full list)''''':''' [[α-Ethyl-α-methylthiobutyrolactone|α-EMTBL]]
+
* ''Positive modulators (abridged; see [[Template:GABAAR PAMs|here]] for a full list):'' [[α-Ethyl-α-methylthiobutyrolactone|α-EMTBL]]
* [[Alcohol]]s (e.g., [[ethanol]])
+
* [[Alcohol]]s (e.g., [[alcohol (drug)|drinking alcohol]], [[tert-Amyl alcohol|2M2B]])
 +
* [[Anabolic steroid]]s
 
* [[Avermectin]]s (e.g., [[ivermectin]])
 
* [[Avermectin]]s (e.g., [[ivermectin]])
 
* [[Barbiturate]]s (e.g., [[phenobarbital]])
 
* [[Barbiturate]]s (e.g., [[phenobarbital]])
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* [[Loreclezole]]
 
* [[Loreclezole]]
 
* [[Monastrol]]
 
* [[Monastrol]]
* [[Neuroactive steroid]]s (e.g., [[allopregnanolone]], [[cholesterol]])
+
* [[Neuroactive steroid]]s (e.g., [[allopregnanolone]], [[cholesterol]], [[THDOC]])
 
* [[Niacin]]
 
* [[Niacin]]
 
* [[Nicotinamide|Nicotinamide (niacinamide)]]
 
* [[Nicotinamide|Nicotinamide (niacinamide)]]
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* [[Volatility (chemistry)|Volatiles]]/[[gas]]es (e.g., [[chloral hydrate]], [[chloroform]], [[diethyl ether]], [[paraldehyde]], [[sevoflurane]])
 
* [[Volatility (chemistry)|Volatiles]]/[[gas]]es (e.g., [[chloral hydrate]], [[chloroform]], [[diethyl ether]], [[paraldehyde]], [[sevoflurane]])
  
* '''Antagonists:''' [[Bicuculline]]
+
* ''Antagonists:'' [[Bicuculline]]
 
* [[Coriamyrtin]]
 
* [[Coriamyrtin]]
 
* [[Dihydrosecurinine]]
 
* [[Dihydrosecurinine]]
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* [[Tutin (toxin)|Tutin]]
 
* [[Tutin (toxin)|Tutin]]
  
* '''NAMs:''' [[5-Ethyl-5-(1,3-dimethylbut-1'-enyl)barbituric acid|1,3M1B]]
+
* ''Negative modulators:'' [[5-Ethyl-5-(1,3-dimethylbut-1'-enyl)barbituric acid|1,3M1B]]
 
* [[5-Ethyl-5-(3-methylbut-2'-enyl)barbituric acid|3M2B]]
 
* [[5-Ethyl-5-(3-methylbut-2'-enyl)barbituric acid|3M2B]]
 +
* [[11-Ketoprogesterone]]
 
* [[17-Phenylandrostenol]]
 
* [[17-Phenylandrostenol]]
 
* [[α5IA|α5IA (LS-193,268)]]
 
* [[α5IA|α5IA (LS-193,268)]]
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* [[Propyl β-carboline-3-carboxylate|β-CCP]]
 
* [[Propyl β-carboline-3-carboxylate|β-CCP]]
 
* [[β-Ethyl-β-methyl-γ-butyrolactone|β-EMGBL]]
 
* [[β-Ethyl-β-methyl-γ-butyrolactone|β-EMGBL]]
 +
* [[Anabolic steroid]]s
 
* [[Amiloride]]
 
* [[Amiloride]]
 
* [[Anisatin]]
 
* [[Anisatin]]
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* [[Basmisanil]]
 
* [[Basmisanil]]
 
* [[Bemegride]]
 
* [[Bemegride]]
 +
* [[Bicyclic phosphate]]s ([[TBPS]], [[TBPO]], [[IPTBO]])
 +
* [[BIDN]]
 
* [[Bilobalide]]
 
* [[Bilobalide]]
 +
* [[Bupropion]]
 
* [[5-(2-Cyclohexylideneethyl)-5-ethylbarbituric acid|CHEB]]
 
* [[5-(2-Cyclohexylideneethyl)-5-ethylbarbituric acid|CHEB]]
 +
* [[Chlorophenylsilatrane]]
 
* [[Cicutoxin]]
 
* [[Cicutoxin]]
 
* [[Cloflubicyne]]
 
* [[Cloflubicyne]]
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* [[DMCM]]
 
* [[DMCM]]
 
* [[5,7-Dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one|DMPC]]
 
* [[5,7-Dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one|DMPC]]
* [[Ethynylbicycloorthobenzoate|EBOB]]
+
* [[EBOB]]
 
* [[Etbicyphat]]
 
* [[Etbicyphat]]
 
* [[FG-7142|FG-7142 (ZK-31906)]]
 
* [[FG-7142|FG-7142 (ZK-31906)]]
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* [[Flurothyl]]
 
* [[Flurothyl]]
 
* [[Furosemide]]
 
* [[Furosemide]]
 +
* [[Golexanolone]]
 
* [[Iomazenil (123I)|Iomazenil (<sup>123</sup>I)]]
 
* [[Iomazenil (123I)|Iomazenil (<sup>123</sup>I)]]
 +
* [[IPTBO]]
 
* [[Isopregnanolone|Isopregnanolone (sepranolone)]]
 
* [[Isopregnanolone|Isopregnanolone (sepranolone)]]
 
* [[L-655,708]]
 
* [[L-655,708]]
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* [[Naltrexone]]
 
* [[Naltrexone]]
 
* [[Nicardipine]]
 
* [[Nicardipine]]
 +
* [[Nonsteroidal antiandrogen]]s (e.g., [[apalutamide]], [[bicalutamide]], [[enzalutamide]], [[flutamide]], [[nilutamide]])
 
* [[Oenanthotoxin]]
 
* [[Oenanthotoxin]]
* [[Pentetrazol|Pentetrazol (metrazol)]]
+
* [[Pentylenetetrazol|Pentylenetetrazol (pentetrazol)]]
 
* [[Phenylsilatrane]]
 
* [[Phenylsilatrane]]
* [[Picrotoxin]] (i.e., [[picrotin]] and [[picrotoxinin]])
+
* [[Picrotoxin]] (i.e., [[picrotin]], [[picrotoxinin]] and [[dihydropicrotoxinin]])
 
* [[Pregnenolone sulfate]]
 
* [[Pregnenolone sulfate]]
 
* [[Propybicyphat]]
 
* [[Propybicyphat]]
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* [[TB-21007]]
 
* [[TB-21007]]
 
* [[t-Butylbicycloorthobenzoate|TBOB]]
 
* [[t-Butylbicycloorthobenzoate|TBOB]]
* [[t-Butylbicyclophosphorothionate|TBPS]]
+
* [[TBPS]]
 
* [[TCS-1105]]
 
* [[TCS-1105]]
 
* [[Terbequinil]]
 
* [[Terbequinil]]
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* [[ZK-93426]]
 
* [[ZK-93426]]
  
     | group2 = [[GABAA-rho receptor|GABA<sub>A</sub>-ρ]]
+
     | group2 = {{abbrlink|GABA<sub>A</sub>-ρ|γ-Aminobutyric acid A-rho receptor}}
     | list2  =
+
     | list2  =  
* '''Agonists:''' [[BL-1020]]
+
* ''Agonists:'' [[BL-1020]]
 
* [[(Z)-4-Amino-2-butenoic acid|CACA]]
 
* [[(Z)-4-Amino-2-butenoic acid|CACA]]
 
* [[(+)-cis-2-Aminomethylcyclopropane carboxylic acid|CAMP]]
 
* [[(+)-cis-2-Aminomethylcyclopropane carboxylic acid|CAMP]]
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* [[Tolgabide]]
 
* [[Tolgabide]]
  
* '''PAMs:''' [[Lanthanide]]s
+
* ''Positive modulators:'' [[Allopregnanolone]]
 +
* [[Alphaxolone]]
 +
* [[Allotetrahydrodeoxycorticosterone|ATHDOC]]
 +
* [[Lanthanide]]s
  
* '''Antagonists:''' [[(S)-4-Amino-2-methylbutanoic acid|(S)-2-MeGABA]]
+
* ''Antagonists:'' [[(S)-4-Amino-2-methylbutanoic acid|(S)-2-MeGABA]]
 
* [[(S)-(4-Aminocyclopent-1-enyl)butylphosphinic acid|(S)-4-ACPBPA]]
 
* [[(S)-(4-Aminocyclopent-1-enyl)butylphosphinic acid|(S)-4-ACPBPA]]
 
* [[(S)-4-Aminocyclopent-1-ene-1-carboxylic acid|(S)-4-ACPCA]]
 
* [[(S)-4-Aminocyclopent-1-ene-1-carboxylic acid|(S)-4-ACPCA]]
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* [[(Z)-3-((Aminoiminomethyl)thio)prop-2-enoic acid|ZAPA]]
 
* [[(Z)-3-((Aminoiminomethyl)thio)prop-2-enoic acid|ZAPA]]
  
* '''NAMs:''' [[Bilobalide]]
+
* ''Negative modulators:'' [[5α-Dihydroprogesterone]]
 +
* [[Bilobalide]]
 +
* [[Loreclezole]]
 
* [[Picrotoxin]] ([[picrotin]], [[picrotoxinin]])
 
* [[Picrotoxin]] ([[picrotin]], [[picrotoxinin]])
 +
* [[Pregnanolone]]
 
* [[ROD-188]]
 
* [[ROD-188]]
 +
* [[Tetrahydrodeoxycorticosterone|THDOC]]
 
* [[Zinc]]
 
* [[Zinc]]
  
    | group3 = [[GABAB receptor|GABA<sub>B</sub>]]
+
  }}
     | list3 =
+
 
* '''Agonists:''' [[1,4-Butanediol]]
+
  | group2 = [[Metabotropic]]
 +
  |  list2 = {{Navbox|subgroup
 +
  | groupstyle = text-align:center;
 +
  | groupwidth = 5em
 +
 
 +
    | group1 = {{abbrlink|GABA<sub>B</sub>|γ-Aminobutyric acid B receptor}}
 +
     | list1 =  
 +
* ''Agonists:'' [[1,4-Butanediol]]
 +
* [[4-Fluorophenibut]]
 
* [[Aceburic acid]]
 
* [[Aceburic acid]]
 
* [[Arbaclofen]]
 
* [[Arbaclofen]]
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* [[gamma-Hydroxyvaleric acid|GHV]]
 
* [[gamma-Hydroxyvaleric acid|GHV]]
 
* [[gamma-Valerolactone|GVL]]
 
* [[gamma-Valerolactone|GVL]]
 +
* [[Isovaline]]
 
* [[Lesogaberan]]
 
* [[Lesogaberan]]
 
* [[Phenibut]]
 
* [[Phenibut]]
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* [[SL 75102]]
 
* [[SL 75102]]
 
* [[Tolgabide]]
 
* [[Tolgabide]]
 +
* [[Tolibut]]
  
* '''PAMs:''' [[ADX-71441]]
+
* ''Positive modulators:'' [[ADX-71441]]
 
* [[BHF-177]]
 
* [[BHF-177]]
 
* [[BHFF]]
 
* [[BHFF]]
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* [[GS-39783]]
 
* [[GS-39783]]
 
* [[rac-BHFF]]
 
* [[rac-BHFF]]
 +
* [[KK-92A]]
  
* '''Antagonists:''' [[2-Hydroxysaclofen]]
+
* ''Antagonists:'' [[2-Hydroxysaclofen]]
 
* [[CGP-35348]]
 
* [[CGP-35348]]
 
* [[CGP-46381]]
 
* [[CGP-46381]]
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* [[SKF-97541]]
 
* [[SKF-97541]]
  
* '''NAMs:''' "Compound 14"[http://www.ncbi.nlm.nih.gov/pubmed/25050158]
+
* ''Negative modulators:'' [[Compound 14]]
  
 
   }}
 
   }}
  
   | group2 = [[Neurotransmitter transporter|Transporter]]<br /><small>([[GABA reuptake inhibitor|blockers]])</small>
+
   | below =  
  | list2  = {{Navbox subgroup
+
;See also
 
+
: ''[[Template:Receptor modulators|Receptor/signaling modulators]] ''
    | group1 = [[GABA transporter|GAT]]
+
: ''[[Template:GABAA receptor positive modulators|GABA<sub>A</sub> receptor positive modulators]] ''
    | list1  =
+
: ''[[Template:GABA metabolism and transport modulators|GABA metabolism/transport modulators]] ''
* [[4-Aminovaleric acid]]
 
* [[β-Alanine]]
 
* [[Arecaidine]]
 
* [[CI-966]]
 
* [[2,4-Diaminobutyric acid|DABA]]
 
* [[Deramciclane|Deramciclane (EGIS-3886, EGYT-3886)]]
 
* [[EF-1502]]
 
* [[Gabaculine]]
 
* [[Guvacine]]
 
* [[Ibotenic acid]]
 
* [[Muscimol]]
 
* [[Nipecotic acid]]
 
* [[NNC 05-2090]]
 
* [[NO-711]]
 
* [[Riluzole]]
 
* [[SKF-89976A]]
 
* [[SNAP-5114]]
 
* [[trans-4-Aminocrotonic acid|TACA]]
 
* [[Tiagabine]]
 
 
 
    | group2 = [[Vesicular inhibitory amino acid transporter|VIAAT]]
 
    | list2  =
 
* [[β-Alanine]]
 
* [[Bafilomycin A1]]
 
* [[Chicago sky blue 6B]]
 
* [[Evans blue]]
 
* [[GABA]]<!--Competitive-->
 
* [[Glycine]]<!--Competitive-->
 
* [[N-Butyric acid]]
 
* [[Nigericin]]
 
* [[Nipecotic acid]]
 
* [[Valinomycin]]
 
* [[Vigabatrin]]
 
 
 
  }}
 
 
 
  | group3 = [[Enzyme]]<br /><small>([[Enzyme inhibitor|inhibitor]]s)</small>
 
  | list3  = {{Navbox subgroup
 
 
 
    | group1 = [[Glutamate decarboxylase|GAD]]
 
    | list1  =
 
* [[3-Mercaptopropionic acid]]
 
* [[Aminooxyacetic acid|AAOA]]
 
* [[L-Allylglycine|{{smaller|L}}-Allylglycine]]
 
* [[Semicarbazide]]
 
 
 
    | group2 = [[4-Aminobutyrate aminotransferase|GABA-T]]
 
    | list2  =
 
* [[3-Hydrazinopropionic acid]]
 
* [[γ-Acetylenic-GABA]]
 
* [[Aminooxyacetic acid|AOAA]]
 
* [[Ethanolamine-O-sulfate|EOS]]
 
* [[Gabaculine]]
 
* [[Isoniazid]]
 
* [[L-Cycloserine|<small>L</small>-Cycloserine]]
 
* [[Phenelzine]]
 
* [[Phenylethylidenehydrazine|PEH]]
 
* [[Rosmarinic acid]] ([[lemon balm]])
 
* [[Sodium valproate]]
 
* [[Valnoctamide]]
 
* [[Valproate pivoxil]]
 
* [[Valproate semisodium|Valproate semisodium (divalproex sodium)]]
 
* [[Valproic acid]]
 
* [[Valpromide]]
 
* [[Vigabatrin]]
 
 
 
  }}
 
 
 
  | group4 = Others
 
  |  list4 =
 
* '''Precursors:''' [[1,4-Butanediol]]
 
* [[γ-Hydroxybutyrate|GHB]]<!--PMID: 10381791-->
 
* [[γ-Hydroxybutaldehyde|GHBAL]]
 
* [[Glutamate]]
 
* [[Glutamine]]
 
 
 
* '''Cofactors:''' [[Vitamin B6|Vitamin B<sub>6</sub>]]
 
 
 
* '''Others:''' ''GABA-T activators:'' [[3-Methyl-GABA]]
 
 
 
  | below = '''''See also:''' [[Template:GHBergics|GHBergics]] • [[Template:Glutamatergics|Glutamatergics]] • [[Template:Glycinergics|Glycinergics]]''
 
  
 
}}<noinclude>
 
}}<noinclude>

Latest revision as of 15:45, 6 March 2020

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