Difference between revisions of "Template:Glutamate receptor modulators"

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{{Navbox
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{{Navboxes
| name = Glutamate receptor modulators
 
 
  | title = [[Glutamate receptor]] [[receptor modulator|modulator]]s
 
  | title = [[Glutamate receptor]] [[receptor modulator|modulator]]s
 +
| titlestyle = background:#ccccff
 
  | state = {{{state<includeonly>|collapsed</includeonly>}}}
 
  | state = {{{state<includeonly>|collapsed</includeonly>}}}
| listclass = hlist
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  | list1 =  
| groupstyle = text-align:center;
+
{{Ionotropic glutamate receptor modulators}}
 
+
{{Metabotropic glutamate receptor modulators}}
| group1 = [[Ionotropic]]
 
  | list1 = {{Navbox|child
 
| groupstyle = text-align:center;
 
 
 
  | group1 = {{abbrlink|AMPAR|α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor}}
 
  | list1 =
 
* '''Agonists:''' ''Glutamate/active site  agonists:'' [[5-Fluorowillardiine]]
 
* [[Acromelic acid|Acromelic acid (acromelate)]]
 
* [[AMPA]]
 
* [[β-N-Oxalylamino-L-Alanine|BOAA]]
 
* [[Domoic acid]]
 
* [[Glutamate]]
 
* [[Ibotenic acid]]
 
* [[Proline]]
 
* [[Quisqualic acid]]
 
* [[Willardiine]]; ''Positive allosteric modulators:'' [[Aniracetam]]
 
* [[Cyclothiazide]]
 
* [[CX-516]]
 
* [[CX-546]]
 
* [[CX-614]]
 
* [[Farampator|Farampator (CX-691, Org 24448)]]
 
* [[CX-717]]
 
* [[CX-1739]]
 
* [[CX-1942]]
 
* [[Diazoxide]]
 
* [[Hydrochlorothiazide|Hydrochlorothiazide (HCTZ)]]
 
* [[IDRA-21]]
 
* [[LY-392,098]]
 
* [[LY-404,187]]
 
* [[LY-451,646]]
 
* [[LY-503,430]]
 
* [[Mibampator|Mibampator (LY-451,395)]]
 
* [[Org 26576]]
 
* [[Oxiracetam]]
 
* [[PEPA (drug)|PEPA]]
 
* [[PF-04958242]]
 
* [[Piracetam]]
 
* [[Pramiracetam]]
 
* [[S-18986]]
 
* [[S-47445|S-47445 (CX-1632)]]
 
* [[Sunifiram]]
 
* [[Unifiram]]
 
 
 
* '''Antagonists:''' [[ACEA-1011]]
 
* [[ATPO]]
 
* [[Becampanel]]
 
* [[Caroverine]]
 
* [[CNQX]]
 
* [[Dasolampanel]]
 
* [[DNQX]]
 
* [[Fanapanel|Fanapanel (MPQX)]]
 
* [[gamma-D-Glutamylaminomethylsulfonic acid|GAMS]]
 
* [[GYKI-52466]]
 
* [[Kaitocephalin]]
 
* [[Kynurenic acid]]
 
* [[Kynurenine]]<!--As a prodrug of kynurenic acid-->
 
* [[Licostinel|Licostinel (ACEA-1021)]]
 
* [[NBQX]]
 
* [[PNQX]]
 
* [[Selurampanel]]
 
* [[Tezampanel]]
 
* [[Theanine]]
 
* [[Topiramate]]
 
* [[YM90K]]
 
* [[Zonampanel]]; ''Negative allosteric modulators:'' [[Barbiturates]] (e.g., [[pentobarbital]], [[sodium thiopental]])
 
* [[Cyclopropane]]
 
* [[Enflurane]]
 
* [[Ethanol]]
 
* [[Evans blue]]
 
* [[GYKI-53,655]]
 
* [[Halothane]]
 
* [[Irampanel]]
 
* [[Isoflurane]]
 
* [[Perampanel]]
 
* [[Pregnenolone sulfate]]
 
* [[Talampanel]]
 
 
 
  | group2 = {{abbrlink|NMDAR|N-Methyl-D-aspartate receptor}}
 
  | list2 =
 
* '''Agonists:''' ''Glutamate/active site  agonists:'' [[2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid|AMAA]]
 
* [[Aspartate]]
 
* [[Glutamate]]
 
* [[Homocysteic acid|Homocysteic acid (<small>L</small>-HCA)]]
 
* [[Homoquinolinic acid]]
 
* [[Ibotenic acid]]
 
* [[N-Methyl-D-aspartic acid|NMDA]]
 
* [[Proline]]
 
* [[Quinolinic acid]]
 
* [[Tetrazolylglycine]]
 
* [[Theanine]]; ''Glycine site agonists:'' [[β-Fluoro-D-alanine|β-Fluoro-<small>D</small>-alanine]]
 
* [[ACBD (drug)|ACBD]]
 
* [[1-Aminocyclopropanecarboxylic acid|ACC (ACPC)]]
 
* [[ACPD]]
 
* [[AK-51 (drug)|AK-51]]
 
* [[Apimostinel|Apimostinel (NRX-1074)]]
 
* [[B6B21]]
 
* [[Carboxycyclopropylglycine|CCG]]
 
* [[Alanine|<small>D</small>-Alanine]]
 
* [[Cycloserine|<small>D</small>-Cycloserine]]
 
* [[Serine|<small>D</small>-Serine]]
 
* [[N-(3,3-Diphenylpropyl)glycinamide|DHPG]]
 
* [[Dimethylglycine]]
 
* [[Glycine]]
 
* [[HA-966]]
 
* [[L-687,414]]
 
* [[Alanine|<small>L</small>-Alanine]]
 
* [[Serine|<small>L</small>-Serine]]
 
* [[Milacemide]]
 
* [[Neboglamine|Neboglamine (nebostinel)]]
 
* [[Rapastinel|Rapastinel (GLYX-13)]]
 
* [[Sarcosine]]; ''Polyamine site agonists:'' [[Spermidine]]
 
* [[Spermine]]; ''Other positive allosteric modulators:'' [[24S-Hydroxycholesterol]]
 
* [[Dehydroepiandrosterone|DHEA]]
 
* [[Dehydroepiandrosterone sulfate|DHEA sulfate]]
 
* [[Pregnenolone sulfate]]
 
* [[SAGE-718]]
 
 
 
* '''Antagonists:''' ''Competitive antagonists:'' [[AP5|AP5 (APV)]]
 
* [[AP-7 (drug)|AP7]]
 
* [[CGP-37849]]
 
* [[CGP-39551]]
 
* [[CGP-39653]]
 
* [[CGP-40116]]
 
* [[CGS-19755]]
 
* [[3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid|CPP]]
 
* [[Kaitocephalin]]
 
* [[LY-233,053]]
 
* [[LY-235,959]]
 
* [[LY-274,614]]
 
* [[MDL-100,453]]
 
* [[Midafotel|Midafotel (d-CPPene)]]
 
* [[NPC-12,626]]
 
* [[NPC-17,742]]
 
* [[PBPD]]
 
* [[PEAQX]]
 
* [[Perzinfotel]]
 
* [[cis-1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid|PPDA]]
 
* [[SDZ-220581]]
 
* [[Selfotel]]; ''Noncompetitive antagonists:'' [[ARR-15,896]]
 
* [[Caroverine]]
 
* [[Dexanabinol]]
 
* [[FPL-12495]]
 
* [[FR-115,427]]
 
* [[Hodgkinsine]]
 
* [[Magnesium]]
 
* [[MDL-27,266]]
 
* [[NPS-1506]]
 
* [[Psychotridine]]
 
* [[Zinc]]; ''Uncompetitive pore blockers:'' [[2-MDP]]
 
* [[3-HO-PCP]]
 
* [[3-MeO-PCE]]
 
* [[3-MeO-PCMo]]
 
* [[3-MeO-PCP]]
 
* [[4-MeO-PCP]]
 
* [[8a-Phenyldecahydroquinoline|8A-PDHQ]]
 
* [[18-Methoxycoronaridine|18-MC]]
 
* [[Alpha-Endopsychosin|α-Endopsychosin]]
 
* [[Alaproclate]]
 
* [[Amantadine]]
 
* [[Aptiganel]]
 
* [[Arketamine]]
 
* [[ARL-12,495]]
 
* [[ARL-15,896-AR]]
 
* [[ARL-16,247]]
 
* [[Budipine]]
 
* [[Conaridine]]
 
* [[Delucemine]]
 
* [[Dexoxadrol]]
 
* [[Dextrallorphan]]
 
* [[Dieticyclidine]]
 
* [[Diphenidine]]
 
* [[Dizocilpine]]
 
* [[Ephenidine]]
 
* [[Esketamine]]
 
* [[Etoxadrol]]
 
* [[Eticyclidine]]
 
* [[Fluorolintane]]
 
* [[Gacyclidine]]
 
* [[Ibogaine]]
 
* [[Ibogamine]]
 
* [[Indantadol]]
 
* [[Ketamine]]
 
* [[Ketobemidone]]
 
* [[Lanicemine]]
 
* [[Loperamide]]
 
* [[Memantine]]
 
* [[Methadone]] ([[Levomethadone]])
 
* [[Methorphan]] ([[Dextromethorphan]]
 
* [[Levomethorphan]])
 
* [[Methoxetamine]]
 
* [[Methoxphenidine]]
 
* [[Milnacipran]]
 
* [[Morphanol]] ([[Dextrorphan]]
 
* [[Levorphanol]])
 
* [[NEFA (drug)|NEFA]]
 
* [[Neramexane]]
 
* [[Nitromemantine]]
 
* [[Nitrous oxide]]
 
* [[Noribogaine]]
 
* [[Norketamine]]
 
* [[Orphenadrine]]
 
* [[PCPr]]
 
* [[PD-137889]]
 
* [[Pethidine|Pethidine (meperidine)]]
 
* [[Phencyclamine]]
 
* [[Phencyclidine]]
 
* [[Propoxyphene]]
 
* [[Remacemide]]
 
* [[Rhynchophylline]]
 
* [[Rimantadine]]
 
* [[Rolicyclidine]]
 
* [[Sabeluzole]]
 
* [[Tabernanthine]]
 
* [[Tenocyclidine]]
 
* [[Tiletamine]]
 
* [[Tramadol]]
 
* [[Xenon]]; ''Glycine site antagonists:'' [[4-Chlorokynurenine|4-Cl-KYN (AV-101)]]
 
* [[5,7-Dichlorokynurenic acid|5,7-DCKA]]
 
* [[7-Chlorokynurenate|7-CKA]]
 
* [[1-Aminocyclopropane-1-carboxylic acid|ACC]]
 
* [[ACEA-1011]]
 
* [[ACEA-1328]]
 
* [[AV-101]]
 
* [[Carisoprodol]]
 
* [[CGP-39653]]
 
* [[CNQX]]
 
* [[DNQX]]
 
* [[Felbamate]]
 
* [[Gavestinel]]
 
* [[GV-196,771]]
 
* [[Kynurenic acid]]
 
* [[Kynurenine]]<!--As a prodrug of kynurenic acid-->
 
* [[L-689,560]]
 
* [[L-701,324]]
 
* [[Licostinel|Licostinel (ACEA-1021)]]
 
* [[LU-73,068]]
 
* [[MDL-105,519]]
 
* [[Meprobamate]]
 
* [[MRZ 2/576]]
 
* [[PNQX]]
 
* [[ZD-9379]]; ''NR2B subunit antagonists:'' [[Besonprodil]]
 
* [[CERC-301|CERC-301 (MK-0657)]]
 
* [[CO-101,244|CO-101,244 (PD-174,494)]]
 
* [[Eliprodil]]
 
* [[Haloperidol]]
 
* [[Ifenprodil]]
 
* [[Isoxsuprine]]
 
* [[Nylidrin]]
 
* [[Ro8-4304]]
 
* [[Ro25-6981]]
 
* [[Traxoprodil]]; ''Polyamine site antagonists:'' [[Arcaine]]
 
* [[Co 101676]]
 
* [[1,3-Diaminopropane|Diaminopropane]]
 
* [[Diethylenetriamine]]
 
* [[Huperzine A]]
 
* [[Putrescine]]
 
* [[Ro 25-6981]]; ''Unclassified/unsorted antagonists:'' [[Bumetanide]]
 
* [[Chloroform]]
 
* [[Cyclopropane]]
 
* [[D-α-Aminoadipate|<small>D</small>-αAA]]
 
* [[Diethyl ether]]
 
* [[Enflurane]]
 
* [[Ethanol]]
 
* [[Flufenamic acid]]
 
* [[Flupirtine]]
 
* [[Furosemide]]
 
* [[Halothane]]
 
* [[Ipenoxazone|Ipenoxazone (MLV-6976)]]
 
* [[Isoflurane]]
 
* [[Metaphit]]<!--Irreversible-->
 
* [[Methoxyflurane]]
 
* [[Niflumic acid]]
 
* [[Pentamidine isethionate]]
 
* [[Piretanide]]
 
* [[Toluene]]
 
* [[Transcrocetin]] ([[saffron]])
 
* [[1,1,1-Trichloroethane|Trichloroethane]]
 
* [[2,2,2-Trichloroethanol|Trichloroethanol]]
 
* [[Trichloroethylene]]
 
* [[Xylene]]
 
 
 
  | group3 = {{abbrlink|Kainate|Kainate receptor}}
 
  | list3 =
 
* '''Agonists:''' ''Glutamate/active site  agonists:'' [[5-Bromowillardiine]]
 
* [[5-Iodowillardiine]]
 
* [[Acromelic acid|Acromelic acid (acromelate)]]
 
* [[AMPA]]
 
* [[ATPA]]
 
* [[Domoic acid]]
 
* [[Glutamate]]
 
* [[Ibotenic acid]]
 
* [[Kainic acid]]
 
* [[LY-339,434]]
 
* [[Proline]]
 
* [[Quisqualic acid]]
 
* [[SYM-2081]]; ''Positive allosteric modulators:'' [[Cyclothiazide]]
 
* [[Diazoxide]]
 
* [[Enflurane]]
 
* [[Halothane]]
 
* [[Isoflurane]]
 
 
 
* '''Antagonists:''' [[ACEA-1011]]
 
* [[CNQX]]
 
* [[Dasolampanel]]
 
* [[DNQX]]
 
* [[gamma-D-Glutamylaminomethylsulfonic acid|GAMS]]
 
* [[Kaitocephalin]]
 
* [[Kynurenic acid]]
 
* [[Licostinel|Licostinel (ACEA-1021)]]
 
* [[LY-382,884]]
 
* [[NBQX]]
 
* [[NS102]]
 
* [[Selurampanel]]
 
* [[Tezampanel]]
 
* [[Theanine]]
 
* [[Topiramate]]
 
* [[UBP-302]]; ''Negative allosteric modulators:'' [[Barbiturates]] (e.g., [[pentobarbital]], [[sodium thiopental]])
 
* [[Enflurane]]
 
* [[Ethanol]]
 
* [[Evans blue]]
 
* [[NS-3763]]
 
* [[Pregnenolone sulfate]]
 
 
 
}}
 
 
 
| group2 = [[Metabotropic]]
 
| list2 = {{Navbox|child
 
| groupstyle = text-align:center;
 
 
 
  | group1 = {{abbrlink|mGluR<sub>1</sub>|Metabotropic glutamate receptor 1}}
 
  | list1 =
 
* '''Agonists:''' [[ACPD]]
 
* [[Dihydroxyphenylglycine|DHPG]]
 
* [[Glutamate]]
 
* [[Ibotenic acid]]
 
* [[Quisqualic acid]]
 
* [[Ro01-6128]]
 
* [[Ro67-4853]]
 
* [[Ro67-7476]]
 
* [[VU-71]]
 
* [[Theanine]]
 
 
 
* '''Antagonists:''' [[BAY 36-7620]]
 
* [[CPCCOEt]]
 
* [[Cyclothiazide]]
 
* [[LY-367,385]]
 
* [[LY-456,236]]
 
* [[MCPG]]
 
* [[NPS-2390]]
 
 
 
  | group2 = {{abbrlink|mGluR<sub>2</sub>|Metabotropic glutamate receptor 2}}
 
  | list2 =
 
* '''Agonists:''' [[Biphenylindanone A|BINA]]
 
* [[CBiPES]]
 
* [[DCG-IV]]
 
* [[Eglumegad]]
 
* [[Glutamate]]
 
* [[Ibotenic acid]]
 
* [[LY-379,268]]
 
* [[LY-404,039|LY-404,039 (pomaglumetad)]]
 
* [[LY-487,379]]
 
* [[LY-566,332]]
 
* [[MGS-0028]]
 
* [[Pomaglumetad methionil|Pomaglumetad methionil (LY-2140023)]]
 
* [[Talaglumetad]]; ''Positive allosteric modulators:'' [[JNJ-40411813|JNJ-40411813 (ADX-71149)]]
 
 
 
* '''Antagonists:''' [[APICA (drug)|APICA]]
 
* [[CECXG]]
 
* [[EGLU]]
 
* [[HYDIA]]
 
* [[LY-307,452]]
 
* [[LY-341,495]]
 
* [[MCPG]]
 
* [[MGS-0039]]
 
* [[PCCG-4]]; ''Negative allosteric modulators:'' [[Decoglurant]]
 
* [[RO4491533]]
 
 
 
  | group3 = {{abbrlink|mGluR<sub>3</sub>|Metabotropic glutamate receptor 3}}
 
  | list3 =
 
* '''Agonists:''' [[CBiPES]]
 
* [[DCG-IV]]
 
* [[Eglumegad]]
 
* [[Glutamate]]
 
* [[Ibotenic acid]]
 
* [[LY-379,268]]
 
* [[LY-404,039|LY-404,039 (pomaglumetad)]]
 
* [[LY-487,379]]
 
* [[MGS-0028]]
 
* [[Pomaglumetad methionil|Pomaglumetad methionil (LY-2140023)]]
 
* [[Talaglumetad]]
 
 
 
* '''Antagonists:''' [[APICA (drug)|APICA]]
 
* [[CECXG]]
 
* [[EGLU]]
 
* [[HYDIA]]
 
* [[LY-307,452]]
 
* [[LY-341,495]]
 
* [[MCPG]]
 
* [[MGS-0039]]; ''Negative allosteric modulators:'' [[Decoglurant]]
 
* [[RO4491533]]
 
 
 
  | group4 = {{abbrlink|mGluR<sub>4</sub>|Metabotropic glutamate receptor 4}}
 
  | list4 =
 
* '''Agonists:''' [[Glutamate]]
 
* [[L-AP4|<small>L</small>-AP4]]
 
* [[PHCCC]]
 
* [[VU-001,171]]
 
* [[VU-0155,041]]; ''Positive allosteric modulators:'' [[2-Methyl-6-(phenylethynyl)pyridine|MPEP]]
 
 
 
* '''Antagonists:''' [[CPPG]]
 
* [[MAP4 (drug)|MAP4]]
 
* [[Alpha-methyl-4-phosphonophenylglycine|MPPG]]
 
* [[MSOP (drug)|MSOP]]
 
* [[MTPG]]
 
* [[UBP-1112]]
 
 
 
  | group5 = {{abbrlink|mGluR<sub>5</sub>|Metabotropic glutamate receptor 5}}
 
  | list5 =
 
* '''Agonists:''' [[ACPD]]
 
* [[ADX-47273]]
 
* [[CDPPB]]
 
* [[Chlorohydroxyphenylglycine|CHPG]]
 
* [[1-(3-fluorophenyl)-N-((3-fluorophenyl)methylideneamino)methanimine|DFB]]
 
* [[Dihydroxyphenylglycine|DHPG]]
 
* [[Glutamate]]
 
* [[Ibotenic acid]]
 
* [[Quisqualic acid]]
 
* [[VU-1545]]
 
 
 
* '''Antagonists:''' [[CTEP]]
 
* [[DMeOB]]
 
* [[LY-344,545]]
 
* [[Mavoglurant]]
 
* [[MCPG]]
 
* [[NPS-2390]]
 
* [[Remeglurant]]
 
* [[SIB-1757]]
 
* [[SIB-1893]]; ''Negative allosteric modulators:'' [[Basimglurant]]
 
* [[Dipraglurant]]
 
* [[Fenobam]]
 
* [[GRN-529]]
 
* [[2-Methyl-6-(phenylethynyl)pyridine|MPEP]]
 
* [[MTEP]]
 
* [[Raseglurant]]
 
 
 
  | group6 = {{abbrlink|mGluR<sub>6</sub>|Metabotropic glutamate receptor 6}}
 
  | list6 =
 
* '''Agonists:''' [[Glutamate]]
 
* [[L-AP4|<small>L</small>-AP4]]
 
 
 
* '''Antagonists:''' [[CPPG]]
 
* [[MAP4 (drug)|MAP4]]
 
* [[Alpha-methyl-4-phosphonophenylglycine|MPPG]]
 
* [[MSOP (drug)|MSOP]]
 
* [[MTPG]]
 
* [[UBP-1112]]
 
 
 
  | group7 = {{abbrlink|mGluR<sub>7</sub>|Metabotropic glutamate receptor 7}}
 
  | list7 =
 
* '''Agonists:''' [[AMN082]]
 
* [[Glutamate]]
 
* [[L-AP4|<small>L</small>-AP4]]
 
 
 
* '''Antagonists:''' [[CPPG]]
 
* [[MAP4 (drug)|MAP4]]
 
* [[MMPIP]]
 
* [[Alpha-methyl-4-phosphonophenylglycine|MPPG]]
 
* [[MSOP (drug)|MSOP]]
 
* [[MTPG]]
 
* [[UBP-1112]]
 
 
 
  | group8 = {{abbrlink|mGluR<sub>8</sub>|Metabotropic glutamate receptor 8}}
 
  | list8 =
 
* '''Agonists:''' [[DCPG]]
 
* [[Glutamate]]
 
* [[L-AP4|<small>L</small>-AP4]]
 
 
 
* '''Antagonists:''' [[CPPG]]
 
* [[MAP4 (drug)|MAP4]]
 
* [[Alpha-methyl-4-phosphonophenylglycine|MPPG]]
 
* [[MSOP (drug)|MSOP]]
 
* [[MTPG]]
 
* [[UBP-1112]]
 
 
 
}}
 
 
 
| below = '''''See also:''' [[Template:Receptor modulators|Receptor/signaling modulators]] • [[Template:Glutamate metabolism and transport modulators|Glutamate metabolism and transport modulators]] • [[Template:GABAergics|GABAergics]] • [[Template:GHBergics|GHBergics]] • [[Template:Glycinergics|Glycinergics]]''
 
 
 
 
}}<noinclude>
 
}}<noinclude>
 
{{collapsible option}}
 
{{collapsible option}}
 
[[Category:Drug templates by receptor, channel, or pump]]
 
[[Category:Drug templates by receptor, channel, or pump]]
 
</noinclude>
 
</noinclude>

Latest revision as of 10:57, 27 August 2017

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