Difference between revisions of "Template:Ion channel modulators"
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{{Navbox | {{Navbox | ||
| name = Ion channel modulators | | name = Ion channel modulators | ||
| − | | title = [[Ion channel modulator]]s | + | | title = [[Channel modulator|Ion channel modulator]]s |
| state = {{{state<includeonly>|collapsed</includeonly>}}} | | state = {{{state<includeonly>|collapsed</includeonly>}}} | ||
| listclass = hlist | | listclass = hlist | ||
| groupstyle = text-align:center; | | groupstyle = text-align:center; | ||
| − | | group1 = [[Calcium channel|Calcium]] | + | | group1 = [[Calcium channel|Calcium]] |
| list1 = {{Navbox|child | | list1 = {{Navbox|child | ||
| groupstyle = text-align:center; | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| − | | group1 = [[Calcium channel blocker|Blocker]]s | + | | group1 = {{abbrlink|VDCCs|Voltage-dependent calcium channels}} |
| − | + | | list1 = {{Navbox|child | |
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = [[Calcium channel blocker|Blocker]]s | ||
| + | | list1 = | ||
* '''[[L-type calcium channel|L-type-selective]]:''' ''[[Dihydropyridine]]s:'' [[Amlodipine]] | * '''[[L-type calcium channel|L-type-selective]]:''' ''[[Dihydropyridine]]s:'' [[Amlodipine]] | ||
* [[Aranidipine]] | * [[Aranidipine]] | ||
| Line 33: | Line 39: | ||
* [[Levniguldipine]] | * [[Levniguldipine]] | ||
* [[Manidipine]] | * [[Manidipine]] | ||
| − | * [[Mepirodipine]] | + | * [[Barnidipine|Mepirodipine]] |
* [[Mesudipine]] | * [[Mesudipine]] | ||
* [[Nicardipine]] | * [[Nicardipine]] | ||
| Line 47: | Line 53: | ||
* [[Palonidipine]] | * [[Palonidipine]] | ||
* [[Pranidipine]] | * [[Pranidipine]] | ||
| − | * [[Ryodipine]] | + | * [[Riodipine|Ryodipine (riodipine)]] |
* [[Sagandipine]] | * [[Sagandipine]] | ||
* [[Sornidipine]] | * [[Sornidipine]] | ||
| Line 57: | Line 63: | ||
* [[Iprotiazem]] | * [[Iprotiazem]] | ||
* [[Nictiazem]] | * [[Nictiazem]] | ||
| − | * [[Siratiazem]]; ''[[Phenylalkylamine]]s:'' [[Anipamil]] | + | * [[Siratiazem]]; ''[[Arylalkylamine|Phenylalkylamine]]s:'' [[Anipamil]] |
* [[Dagapamil]] | * [[Dagapamil]] | ||
* [[Devapamil]] | * [[Devapamil]] | ||
| Line 78: | Line 84: | ||
* [[Fantofarone]] | * [[Fantofarone]] | ||
* [[SR-33805]]<!--allosteric blocker--> | * [[SR-33805]]<!--allosteric blocker--> | ||
| + | * [[Tetrahydropalmatine]] | ||
* '''[[N-type calcium channel|N-type-selective]]:''' [[ω-Conotoxin]]s | * '''[[N-type calcium channel|N-type-selective]]:''' [[ω-Conotoxin]]s | ||
| Line 149: | Line 156: | ||
* [[Elpetrigine]] | * [[Elpetrigine]] | ||
* [[Ethadione]] | * [[Ethadione]] | ||
| + | * [[Alcohol (drug)|Ethanol (alcohol)]] | ||
* [[Ethosuximide]] | * [[Ethosuximide]] | ||
* [[Fasudil]] | * [[Fasudil]] | ||
* [[Fendiline]] | * [[Fendiline]] | ||
* [[Fostedil]] | * [[Fostedil]] | ||
| + | * [[Imepitoin]] | ||
* [[JTV-519]] | * [[JTV-519]] | ||
* [[Lidoflazine]] | * [[Lidoflazine]] | ||
| Line 165: | Line 174: | ||
* [[Paramethadione]] | * [[Paramethadione]] | ||
* [[Phensuximide]] | * [[Phensuximide]] | ||
| − | * [[Pinaverium]] | + | * [[Pinaverium bromide]] |
* [[Prenylamine]] | * [[Prenylamine]] | ||
* [[Rhynchophylline]] | * [[Rhynchophylline]] | ||
| Line 172: | Line 181: | ||
* [[Sipatrigine]] | * [[Sipatrigine]] | ||
* [[Terodiline]] | * [[Terodiline]] | ||
| − | |||
* [[Tetrandrine]] | * [[Tetrandrine]] | ||
* [[Tolperisone]] | * [[Tolperisone]] | ||
| Line 178: | Line 186: | ||
* [[Valperinol]] | * [[Valperinol]] | ||
| − | | group2 = [[Calcium channel opener| | + | | group2 = [[Calcium channel opener|Activator]]s |
| list2 = | | list2 = | ||
* '''[[L-type calcium channel|L-type-selective]]:''' [[Bay K8644]] | * '''[[L-type calcium channel|L-type-selective]]:''' [[Bay K8644]] | ||
| + | |||
| + | }} | ||
}} | }} | ||
| − | | group2 = [[Potassium channel|Potassium]] | + | | group2 = [[Potassium channel|Potassium]] |
| list2 = {{Navbox|child | | list2 = {{Navbox|child | ||
| groupstyle = text-align:center; | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| − | | group1 = [[Potassium channel blocker|Blocker]]s | + | | group1 = {{abbrlink|VGKCs|Voltage-gated potassium channels}} |
| − | + | | list1 = {{Navbox|child | |
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = [[Potassium channel blocker|Blocker]]s | ||
| + | | list1 = | ||
* [[3,4-Diaminopyridine|3,4-Diaminopyridine (amifampridine)]] | * [[3,4-Diaminopyridine|3,4-Diaminopyridine (amifampridine)]] | ||
* [[4-Aminopyridine|4-Aminopyridine (fampridine/dalfampridine)]] | * [[4-Aminopyridine|4-Aminopyridine (fampridine/dalfampridine)]] | ||
| Line 207: | Line 223: | ||
* [[E-4031]] | * [[E-4031]] | ||
* [[Hanatoxin]] | * [[Hanatoxin]] | ||
| + | * [[HgeTx1]] | ||
| + | * [[HsTx1]] | ||
* [[Ibutilide]] | * [[Ibutilide]] | ||
* [[Inakalant]] | * [[Inakalant]] | ||
* [[Kaliotoxin]] | * [[Kaliotoxin]] | ||
* [[Linopirdine]] | * [[Linopirdine]] | ||
| + | * [[Lolitrem B]] | ||
* [[Maurotoxin]] | * [[Maurotoxin]] | ||
* [[Nifekalant]] | * [[Nifekalant]] | ||
| Line 216: | Line 235: | ||
* [[Paxilline]] | * [[Paxilline]] | ||
* [[Pinokalant]] | * [[Pinokalant]] | ||
| + | * [[Quinidine]] | ||
* [[ShK-186]]<!--Kv1.3-selective--> | * [[ShK-186]]<!--Kv1.3-selective--> | ||
* [[Sotalol]] | * [[Sotalol]] | ||
| Line 223: | Line 243: | ||
* [[Vernakalant]] | * [[Vernakalant]] | ||
| − | + | * '''[[hERG]] (KCNH2, K<sub>v</sub>11.1)-specific:''' [[Ajmaline]] | |
| − | |||
| − | * '''[[hERG]] | ||
* [[Amiodarone]] | * [[Amiodarone]] | ||
* [[AmmTX3]] | * [[AmmTX3]] | ||
| Line 254: | Line 272: | ||
* [[PNU-282,987]] | * [[PNU-282,987]] | ||
* [[Promethazine]] | * [[Promethazine]] | ||
| + | * [[Quinidine]] | ||
| + | * [[Ranolazine]] | ||
* [[Roxithromycin]] | * [[Roxithromycin]] | ||
* [[Sertindole]] | * [[Sertindole]] | ||
| Line 265: | Line 285: | ||
* [[Vernakalant]] | * [[Vernakalant]] | ||
| − | + | * '''[[KCNQ|KCNQ (K<sub>v</sub>7)]]-specific:''' [[Linopirdine]] | |
| − | + | * [[XE-991]] | |
| − | * '''[[ATP-sensitive potassium channel|K<sub>ATP</sub> | + | * [[Ssm spooky toxin|Spooky toxin (SsTx)]] |
| + | |||
| + | | group2 = [[Potassium channel opener|Activator]]s | ||
| + | | list2 = | ||
| + | * '''[[KCNQ|KCNQ (K<sub>v</sub>7)]]-specific:''' [[Flupirtine]] | ||
| + | * [[Retigabine]] | ||
| + | |||
| + | }} | ||
| + | |||
| + | | group2 = {{abbrlink|IRKs|Inwardly rectifying potassium channel}} | ||
| + | | list2 = {{Navbox|child | ||
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = [[Potassium channel blocker|Blocker]]s | ||
| + | | list1 = | ||
| + | * '''{{abbrlink|K<sub>ATP</sub>|ATP-sensitive potassium channel}}-specific:''' [[Acetohexamide]] | ||
| + | * [[Carbutamide]] | ||
| + | * [[Chlorpropamide]] | ||
| + | * [[Glibenclamide|Glibenclamide (glyburide)]] | ||
| + | * [[Glibornuride]] | ||
| + | * [[Glicaramide]] | ||
| + | * [[Gliclazide]] | ||
| + | * [[Glimepiride]] | ||
| + | * [[Glipizide]] | ||
| + | * [[Gliquidone]] | ||
| + | * [[Glisoxepide]] | ||
| + | * [[Glyclopyramide]] | ||
| + | * [[Glycyclamide]] | ||
| + | * [[Metahexamide]] | ||
| + | * [[Mitiglinide]] | ||
| + | * [[Nateglinide]] | ||
| + | * [[Repaglinide]] | ||
| + | * [[Tolazamide]] | ||
| + | * [[Tolbutamide]] | ||
| + | |||
| + | * '''{{abbrlink|GIRK|G protein-coupled inwardly-rectifying potassium channel}}-specific:''' [[Barium]] | ||
| + | * [[Caramiphen]] | ||
| + | * [[Cloperastine]] | ||
| + | * [[Clozapine]] | ||
| + | * [[Dextromethorphan]] | ||
| + | * [[Ethosuximide]] | ||
| + | * [[Ifenprodil]] | ||
| + | * [[Tertiapin]] | ||
| + | * [[Tipepidine]] | ||
| + | |||
| + | | group2 = [[Potassium channel opener|Activator]]s | ||
| + | | list2 = | ||
| + | * '''{{abbrlink|K<sub>ATP</sub>|ATP-sensitive potassium channel}}-specific:''' [[Aprikalim]] | ||
* [[Bimakalim]] | * [[Bimakalim]] | ||
* [[Cromakalim]] | * [[Cromakalim]] | ||
| + | * [[Diazoxide]] | ||
* [[Emakalim]] | * [[Emakalim]] | ||
* [[Levcromakalim]] | * [[Levcromakalim]] | ||
* [[Mazokalim]] | * [[Mazokalim]] | ||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
* [[Minoxidil]] | * [[Minoxidil]] | ||
* [[Naminidil]] | * [[Naminidil]] | ||
* [[Nicorandil]] | * [[Nicorandil]] | ||
* [[Pinacidil]] | * [[Pinacidil]] | ||
| − | * [[ | + | * [[Rilmakalim]] |
| − | * [[Rottlerin]] | + | * [[Sarakalim]] |
| + | |||
| + | * '''{{abbrlink|GIRK|G protein-coupled inwardly-rectifying potassium channel}}-specific:''' [[ML-297|ML-297 (VU0456810)]] | ||
| + | |||
| + | }} | ||
| + | |||
| + | | group3 = {{abbrlink|K<sub>Ca</sub>|Calcium-activated potassium channel}} | ||
| + | | list3 = {{Navbox|child | ||
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = [[Potassium channel blocker|Blocker]]s | ||
| + | | list1 = | ||
| + | * '''[[BK channel|BK<sub>Ca</sub>]]-specific:''' [[Alcohol (drug)|Ethanol (alcohol)]] | ||
| + | * [[GAL-021]] | ||
| + | |||
| + | | group2 = [[Potassium channel opener|Activator]]s | ||
| + | | list2 = | ||
| + | * '''[[BK channel|BK<sub>Ca</sub>]]-specific:''' [[Flufenamic acid]] | ||
| + | * [[Meclofenamic acid]] | ||
| + | * [[Niflumic acid]] | ||
| + | * [[Nimesulide]] | ||
| + | * [[Rottlerin|Rottlerin (mallotoxin)]] | ||
| + | * [[Tolfenamic acid]] | ||
| + | |||
| + | }} | ||
| + | |||
| + | | group4 = {{abbrlink|K2Ps|Tandem pore domain potassium channel}} | ||
| + | | list4 = {{Navbox|child | ||
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = [[Potassium channel blocker|Blocker]]s | ||
| + | | list1 = | ||
| + | * [[12-O-Tetradecanoylphorbol-13-acetate]] | ||
| + | * [[Arachidonic acid]] | ||
| + | * [[Fluoxetine]] | ||
| + | * [[Norfluoxetine]] | ||
| + | |||
| + | | group2 = [[Potassium channel opener|Activator]]s | ||
| + | | list2 = | ||
| + | * [[Riluzole]] | ||
| + | |||
| + | }} | ||
}} | }} | ||
| − | | group3 = [[Sodium channel|Sodium]] | + | | group3 = [[Sodium channel|Sodium]] |
| list3 = {{Navbox|child | | list3 = {{Navbox|child | ||
| groupstyle = text-align:center; | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = {{abbrlink|VGSCs|Voltage-gated sodium channels}} | ||
| + | | list1 = {{Navbox|child | ||
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = [[Sodium channel blocker|Blocker]]s | ||
| + | | list1 = | ||
| + | * ''Antianginals:'' [[Ranolazine]] | ||
| − | + | * ''Antiarrhythmics (class I):'' [[Ajmaline]] | |
| − | |||
| − | * | ||
* [[Aprindine]] | * [[Aprindine]] | ||
* [[Disopyramide]] | * [[Disopyramide]] | ||
| Line 310: | Line 425: | ||
* [[Quinidine]] | * [[Quinidine]] | ||
* [[Sparteine]] | * [[Sparteine]] | ||
| − | * [[Tocainide]] | + | * [[Tocainide]] |
| + | |||
| + | * ''Anticonvulsants:'' [[Acetylpheneturide]] | ||
* [[Carbamazepine]] | * [[Carbamazepine]] | ||
* [[Cenobamate]] | * [[Cenobamate]] | ||
| Line 335: | Line 452: | ||
* [[Valproic acid]] | * [[Valproic acid]] | ||
* [[Valpromide]] | * [[Valpromide]] | ||
| − | * [[Zonisamide | + | * [[Zonisamide]] |
| − | + | ||
| − | * | + | * ''Local anesthetics:'' [[3-(p-Fluorobenzoyloxy)tropane|''p''FBT]] |
* [[Amylocaine]] | * [[Amylocaine]] | ||
* [[Articaine]] | * [[Articaine]] | ||
| Line 365: | Line 482: | ||
* [[Risocaine]] | * [[Risocaine]] | ||
* [[Tetracaine]] | * [[Tetracaine]] | ||
| − | * [[Trimecaine]] | + | * [[Trimecaine]] |
| + | |||
| + | * ''Analgesics:'' [[AZD-3161]] | ||
* [[DSP-2230]] | * [[DSP-2230]] | ||
* [[Funapide]] | * [[Funapide]] | ||
| Line 374: | Line 493: | ||
* [[Ralfinamide]] | * [[Ralfinamide]] | ||
* [[Raxatrigine]] | * [[Raxatrigine]] | ||
| − | * [[RG7893|RG7893 (GDC-0287)]] | + | * [[RG7893|RG7893 (GDC-0287)]] |
| + | |||
| + | * ''Toxins:'' [[Conotoxin]]s | ||
* [[Neosaxitoxin]] | * [[Neosaxitoxin]] | ||
* [[Saxitoxin]] | * [[Saxitoxin]] | ||
| − | * [[Tetrodotoxin]] | + | * [[Tetrodotoxin]] |
| + | * [[Zetekitoxin AB]] | ||
| + | |||
| + | * ''Others:'' [[Buprenorphine]] | ||
* [[Evenamide]] | * [[Evenamide]] | ||
| − | * [[Menthol]] | + | * [[Menthol]] ([[Mentha|mint]]) |
* [[Safinamide]] | * [[Safinamide]] | ||
* [[Tricyclic antidepressant]]s | * [[Tricyclic antidepressant]]s | ||
| − | | group2 = [[Sodium channel opener| | + | | group2 = [[Sodium channel opener|Activator]]s |
| list2 = | | list2 = | ||
| − | * | + | * [[Aconitine]] |
| + | * Atracotoxins ([[omega-Atracotoxin|ω-Atracotoxin]], [[Robustoxin]], [[Versutoxin]]) | ||
| + | * [[Batrachotoxin]] | ||
* [[Ciguatoxin]]s | * [[Ciguatoxin]]s | ||
| + | * [[Grayanotoxin]]s | ||
| + | * [[Poneratoxin]] | ||
| + | |||
| + | }} | ||
| + | |||
| + | | group2 = {{abbrlink|ENaC|Epithelial sodium channel}} | ||
| + | | list2 = {{Navbox|child | ||
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| − | * | + | | group1 = [[Sodium channel blocker|Blocker]]s |
| + | | list1 = | ||
| + | * [[Amiloride]] | ||
| + | * [[Benzamil]] | ||
| + | * [[Triamterene]] | ||
| + | |||
| + | | group2 = [[Sodium channel opener|Activator]]s | ||
| + | | list2 = | ||
| + | * [[Solnatide]] | ||
| + | |||
| + | }} | ||
| + | |||
| + | | group3 = {{abbrlink|ASICs|Acid-sensing ion channel}} | ||
| + | | list3 = {{Navbox|child | ||
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = [[Sodium channel blocker|Blocker]]s | ||
| + | | list1 = | ||
| + | * [[A-317567]] | ||
| + | * [[Amiloride]] | ||
| + | * [[Aspirin]] | ||
| + | * [[Ibuprofen]] | ||
| + | * [[PcTX1]] | ||
| + | |||
| + | | group2 = [[Sodium channel opener|Activator]]s | ||
| + | | list2 = | ||
| + | |||
| + | }} | ||
}} | }} | ||
| − | | group4 = [[Chloride channel|Chloride]] | + | | group4 = [[Chloride channel|Chloride]] |
| list4 = {{Navbox|child | | list4 = {{Navbox|child | ||
| groupstyle = text-align:center; | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| − | | group1 = | + | | group1 ={{abbrlink|CaCCs|Calcium-activated chloride channel}} |
| − | | | + | | list1 = {{Navbox|child |
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| − | * [[ | + | | group1 = [[Chloride channel blocker|Blocker]]s |
| − | * [[DIDS]] | + | | list1 = |
| + | * [[Crofelemer]]<!--ANO1--> | ||
| + | * [[DIDS]]<!--ANO1--> | ||
| + | * [[Ethacrynic acid]] | ||
* [[Flufenamic acid]] | * [[Flufenamic acid]] | ||
| + | * [[Fluoxetine]] | ||
* [[Furosemide]] | * [[Furosemide]] | ||
| + | * [[Glibenclamide]] | ||
| + | * [[Mefloquine]] | ||
| + | * [[Mibefradil]] | ||
| + | * [[Niflumic acid]] | ||
| + | |||
| + | | group2 = [[Chloride channel opener|Activator]]s | ||
| + | | list2 = | ||
| + | * [[Carbachol]]<!--ANO1--> | ||
| + | |||
| + | }} | ||
| + | |||
| + | | group2 = {{abbrlink|CFTR|Cystic fibrosis transmembrane conductance regulator}} | ||
| + | | list2 = {{Navbox|child | ||
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = [[Chloride channel blocker|Blocker]]s | ||
| + | | list1 = | ||
* [[Glibenclamide]] | * [[Glibenclamide]] | ||
* [[Lonidamine]] | * [[Lonidamine]] | ||
| + | * [[Piretanide]] | ||
| + | |||
| + | | group2 = [[Chloride channel opener|Activator]]s | ||
| + | | list2 = | ||
| + | * [[1,7-Phenanthroline]] | ||
| + | * [[1,10-Phenanthroline]] | ||
| + | * [[4,7-Phenanthroline]] | ||
| + | * [[7,8-Benzoquinoline]] | ||
| + | * [[Ivacaftor]] | ||
| + | * [[Phenanthridine]] | ||
| + | |||
| + | }} | ||
| + | |||
| + | | group3 = Unsorted | ||
| + | | list3 = {{Navbox|child | ||
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = [[Chloride channel blocker|Blocker]]s | ||
| + | | list1 = | ||
| + | * [[Bumetanide]] | ||
| + | * [[Flufenamic acid]] | ||
* [[Meclofenamic acid]] | * [[Meclofenamic acid]] | ||
* [[Mefenamic acid]] | * [[Mefenamic acid]] | ||
* [[Mepacrine]] | * [[Mepacrine]] | ||
* [[Niflumic acid]] | * [[Niflumic acid]] | ||
| − | |||
* [[Talniflumate]] | * [[Talniflumate]] | ||
* [[Tolfenamic acid]] | * [[Tolfenamic acid]] | ||
* [[Trifluoperazine]] | * [[Trifluoperazine]] | ||
| − | + | | group2 = [[Chloride channel opener|Activator]]s | |
| − | | | + | | list2 = |
| − | + | ||
| − | * [[ | + | }} |
| − | + | ||
| − | + | }} | |
| − | * [[ | + | |
| + | | group5 = Others | ||
| + | | list5 = {{Navbox|child | ||
| + | | groupstyle = text-align:center; | ||
| + | | groupwidth = 5em; | ||
| + | |||
| + | | group1 = {{abbrlink|TRPs|Transient receptor potential channels}} | ||
| + | | list1 = | ||
| + | * See [[Template:Transient receptor potential channel modulators|here]] instead. | ||
| + | |||
| + | | group2 = {{abbrlink|LGICs|Ligand gated ion channels}} | ||
| + | | list2 = | ||
| + | * See [[Template:Pharmacomodulation|here]] instead. | ||
}} | }} | ||
| − | | | + | | below = '''''See also:''' [[Template:Receptor modulators|Receptor/signaling modulators]] • [[Template:Transient receptor potential channel modulators|Transient receptor potential channel modulators]]'' |
| − | |||
}}<noinclude> | }}<noinclude> | ||
Latest revision as of 13:24, 22 July 2019
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