Difference between revisions of "Template:Absolute activities of tibolone and metabolites"
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{| class="wikitable sortable mw-collapsible {{{state<includeonly>|mw-collapsed</includeonly>}}}" style="text-align:left; margin-left:auto; margin-right:auto; border:none;" | {| class="wikitable sortable mw-collapsible {{{state<includeonly>|mw-collapsed</includeonly>}}}" style="text-align:left; margin-left:auto; margin-right:auto; border:none;" | ||
| − | |+ class="nowrap" | {{Navbar|Absolute activities of tibolone and metabolites|mini=y}} Absolute activities (nM) of | + | |+ class="nowrap" | {{Navbar|Absolute activities of tibolone and metabolites|mini=y}} Absolute activities (nM) of <noinclude>[[tibolone]]</noinclude><includeonly>tibolone</includeonly> and metabolites |
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! Compound !! Code name !! {{abbrlink|PR|Progesterone receptor}} !! {{abbrlink|AR|Androgen receptor}} !! {{abbrlink|ERα|Estrogen receptor alpha}} !! {{abbrlink|ERβ|Estrogen receptor beta}} !! {{abbrlink|GR|Glucocorticoid receptor}} !! {{abbrlink|MR|Mineralocorticoid receptor}} | ! Compound !! Code name !! {{abbrlink|PR|Progesterone receptor}} !! {{abbrlink|AR|Androgen receptor}} !! {{abbrlink|ERα|Estrogen receptor alpha}} !! {{abbrlink|ERβ|Estrogen receptor beta}} !! {{abbrlink|GR|Glucocorticoid receptor}} !! {{abbrlink|MR|Mineralocorticoid receptor}} | ||
Revision as of 14:42, 22 June 2020
| Compound | Code name | PR | AR | ERα | ERβ | GR | MR |
|---|---|---|---|---|---|---|---|
| Template:No selflink | ORG-OD-14 | 123 | 1.05 | 4 | 105 | 2410* | 170* |
| Template:No selflink | ORG-OM-38 | 46 | 0.2 | 26 | 300 | 1760* | 30* |
| Template:No selflink | ORG-4094 | 2400* | 135* | 1.7 | 100 | ND* | 1160* |
| Template:No selflink | ORG-30126 | 20000* | ND* | 2.4 | 115 | ND* | 3310* |
| Notes: Values are affinities (nM). Non-italicized values are EC50. Italicized values with an asterisk (*) are IC50. Reference ligands (EC50) were promegestone (5 nM for PR), metribolone (0.1 nM for AR), estradiol (0.018 nM for ERα, 0.08 nM for ERβ), dexamethasone (6 nM for GR), and aldosterone (0.36 nM for MR). Sources: [1] | |||||||
References
- ↑ Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T (August 2009). "Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites". J. Steroid Biochem. Mol. Biol. 116 (1–2): 8–14. doi:10.1016/j.jsbmb.2009.03.008. PMID 19464167.
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