Difference between revisions of "Template:Absolute activities of tibolone and metabolites"
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| {{No selflink|3β-Hydroxytibolone}} || ORG-30126 || ''20000''* || ''{{abbr|ND|No data}}''* || 2.4 || 115 || ''{{abbr|ND|No data}}''* || ''3310''* | | {{No selflink|3β-Hydroxytibolone}} || ORG-30126 || ''20000''* || ''{{abbr|ND|No data}}''* || 2.4 || 115 || ''{{abbr|ND|No data}}''* || ''3310''* | ||
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| − | | colspan="8" style="width: 1px; background-color:#eaecf0; text-align: center;" | '''Notes:''' Values are affinities (nM). Non-italicized values are {{abbrlink|EC<sub>50</sub>|half-maximal effective concentration}}. Italicized values with an asterisk (*) are {{abbrlink|IC<sub>50</sub>|half-maximal inhibitory concentration}}. Reference [[ligand (biochemistry)|ligand]]s (EC<sub>50</sub>) were [[promegestone]] (5 nM for PR), [[metribolone]] (0.1 nM for AR), [[estradiol (medication)|estradiol]] (0.018 nM for ERα, 0.08 nM for ERβ), [[dexamethasone]] (6 nM for GR), and [[aldosterone]] (0.36 nM for MR). '''Sources:''' <noinclude><ref name=" | + | | colspan="8" style="width: 1px; background-color:#eaecf0; text-align: center;" | '''Notes:''' Values are affinities (nM). Non-italicized values are {{abbrlink|EC<sub>50</sub>|half-maximal effective concentration}}. Italicized values with an asterisk (*) are {{abbrlink|IC<sub>50</sub>|half-maximal inhibitory concentration}}. Reference [[ligand (biochemistry)|ligand]]s (EC<sub>50</sub>) were [[promegestone]] (5 nM for PR), [[metribolone]] (0.1 nM for AR), [[estradiol (medication)|estradiol]] (0.018 nM for ERα, 0.08 nM for ERβ), [[dexamethasone]] (6 nM for GR), and [[aldosterone]] (0.36 nM for MR). '''Sources:''' <noinclude><ref name="pmid19464167">{{cite journal | vauthors = Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T | title = Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites | journal = J. Steroid Biochem. Mol. Biol. | volume = 116 | issue = 1-2 | pages = 8–14 | date = August 2009 | pmid = 19464167 | doi = 10.1016/j.jsbmb.2009.03.008 | url = }}</ref></noinclude><includeonly>See template.</includeonly> |
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Revision as of 12:53, 22 June 2020
| Compound | Code name | PR | AR | ERα | ERβ | GR | MR |
|---|---|---|---|---|---|---|---|
| Template:No selflink | ORG-OD-14 | 123 | 1.05 | 4 | 105 | 2410* | 170* |
| Template:No selflink | ORG-OM-38 | 46 | 0.2 | 26 | 300 | 1760* | 30* |
| Template:No selflink | ORG-4094 | 2400* | 135* | 1.7 | 100 | ND* | 1160* |
| Template:No selflink | ORG-30126 | 20000* | ND* | 2.4 | 115 | ND* | 3310* |
| Notes: Values are affinities (nM). Non-italicized values are EC50. Italicized values with an asterisk (*) are IC50. Reference ligands (EC50) were promegestone (5 nM for PR), metribolone (0.1 nM for AR), estradiol (0.018 nM for ERα, 0.08 nM for ERβ), dexamethasone (6 nM for GR), and aldosterone (0.36 nM for MR). Sources: [1] | |||||||
References
- ↑ Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T (August 2009). "Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites". J. Steroid Biochem. Mol. Biol. 116 (1–2): 8–14. doi:10.1016/j.jsbmb.2009.03.008. PMID 19464167.
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