Template:Cholesterol and steroid metabolism enzymes
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Cholesterol total synthesis
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Metabolism
:
lipid metabolism
–
ketones
/
cholesterol
synthesis
enzymes
/
steroid metabolism
Mevalonate pathway
To
HMG-CoA
Acetyl-Coenzyme A acetyltransferase
HMG-CoA synthase
(regulated step)
Ketogenesis
HMG-CoA lyase
3-hydroxybutyrate dehydrogenase
Thiophorase
To
Mevalonic acid
HMG-CoA reductase
To
DMAPP
Mevalonate kinase
Phosphomevalonate kinase
Pyrophosphomevalonate decarboxylase
Isopentenyl-diphosphate delta isomerase
Geranyl-
Dimethylallyltranstransferase
Geranyl pyrophosphate
To
cholesterol
To
lanosterol
Farnesyl-diphosphate farnesyltransferase
Squalene monooxygenase
Lanosterol synthase
7-Dehydrocholesterol
path
Lanosterol 14α-demethylase
Sterol-C5-desaturase-like
7-Dehydrocholesterol reductase
Desmosterol
path
24-dehydrocholesterol reductase
To
Bile acids
Cholesterol 7α-hydroxylase
Sterol 27-hydroxylase
Steroidogenesis
To
pregnenolone
Side-chain cleavage
To
corticosteroids
aldosterone
:
18-hydroxylase
cortisol
/
cortisone
:
17α-hydroxylase
11β dehydrogenase
HSD11B1
HSD11B2
both:
3β dehydrogenase
21α-hydroxylase
11β-hydroxylase
To
sex hormones
To
androgens
17α-hydroxylase/17,20 lyase
3β dehydrogenase
17β dehydrogenase
5α reductase
1
2
To
estrogens
Aromatase
Other/ungrouped
Steroid metabolism
:
sulfatase
Steroid sulfatase
sulfotransferase
SULT1A1
SULT2A1
Steroidogenic acute regulatory protein
Cholesterol total synthesis
Template:Metabolic navs
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Index of
hormones
Description
Glands
Hormones
thyroid
intermediates
metabolism
mineralocorticoids
Physiology
Development
Disease
Diabetes
Congenital
Neoplasms and cancer
Treatment
Procedures
Drugs
calcium balance
corticosteroids
oral hypoglycemics
pituitary and hypothalamic
thyroid
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Metabolism
Lipid metabolic pathway templates
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