- Monongah Mining disaster, Monongah, West Virginia, 1907 (362 killed)
- Dawson, New Mexico, 1913 (263 killed)
- Cherry Mine disaster, Cherry, Illinois, 1909 (259 killed)
- Darr Mine Disaster, Jacobs Creek, Pennsylvania, 1907 (239 killed)
- Fraterville Mine disaster, Fraterville, Tennessee, 1902 (216 killed)
- Scofield Mine disaster, Scofield, Utah, 1900 (200 killed)
- Mather Mine disaster, Mather, Pennsylvania, 1928 (195 killed)
- Eccles Mine Disaster, Eccles, West Virginia, 1914 (180+ killed)
- Harwick Mine disaster, Cheswick, Pennsylvania, 1904 (179 killed)
- Castle Gate Mine disaster, Castle Gate, Utah, 1924 (171 killed)
- Hanna Mine Disaster, Hanna, Wyoming, 1903 (169 killed)
- Kemmerer Mine disaster, Kemmerer, Wyoming, 1923 (138 killed)
- Dawson, New Mexico, 1923 (123 killed)
- Victor American Hastings Mine Disaster, Ludlow, Colorado, 1917 (121 killed)
- Orient #2 Mine, West Frankfort, Illinois, 1951 (119 killed)
- Benwood Mine Disaster, Benwood, West Virginia, 1924 (119 killed)
- Rolling Mill Mine, Johnstown, Pennsylvania, 1902 (112 killed)
- 1947 Centralia mine disaster, Centralia, Illinois, 1947 (111 killed)
- Avondale Mine Disaster, Plymouth, Pennsylvania, 1869 (110 killed)
- Everettville, West Virginia, 1927 (109 killed)
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