Template:Affinities of selected ligands at the androgen receptor
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| Compound | AR RBA (%) | AR Ki (nM) |
|---|---|---|
| Template:No selflink | 100 | 1.18 |
| Template:No selflink | 136 | 0.87 |
| Template:No selflink | 117 | 1.01 |
| Template:No selflink | 67.0 | 1.76 |
| Template:No selflink | 14.8 | 8.0 |
| Template:No selflink | 13.6 | 8.7 |
| Template:No selflink | 12.5 | 9.5 |
| Template:No selflink | 6.6 | 18 |
| Template:No selflink | 4.9 | 24 |
| Template:No selflink | 2.0 | 58 |
| Template:No selflink | 0.84 | 140 |
| Template:No selflink | 0.079 | 1200 |
| Template:No selflink | 0.00084 | 140,000 |
| Notes: (1) Human skin fibroblasts used for assays. (2) Situation in vivo is different for flutamide and spironolactone due biotransformation. (3) Conflicting findings for spironolactone. Sources: Main: [1][2] Related: [3][4][5] | ||
References
- ↑ Hammerstein, J. (1990). "Antiandrogens: Clinical Aspects". Hair and Hair Diseases. pp. 827–886. doi:10.1007/978-3-642-74612-3_35. ISBN 978-3-642-74614-7.
- ↑ Eil C, Edelson SK (July 1984). "The use of human skin fibroblasts to obtain potency estimates of drug binding to androgen receptors". J. Clin. Endocrinol. Metab. 59 (1): 51–5. doi:10.1210/jcem-59-1-51. PMID 6725525.
- ↑ Brown TR, Rothwell SW, Sultan C, Migeon CJ (June 1981). "Inhibition of androgen binding in human foreskin fibroblasts by antiandrogens". Steroids. 37 (6): 635–48. doi:10.1016/S0039-128X(81)90173-2. PMID 6457421.
- ↑ Breiner M, Romalo G, Schweikert HU (August 1986). "Inhibition of androgen receptor binding by natural and synthetic steroids in cultured human genital skin fibroblasts". Klinische Wochenschrift. 64 (16): 732–7. doi:10.1007/BF01734339. PMID 3762019.
- ↑ Breiner M, Romalo G, Schweikert HU (1986). "Inhibition of androgen receptor binding by drugs in cultured human genital skin fibroblasts". Acta Endocrinologica. 113 (1_Suppl): S152. doi:10.1530/acta.0.111S152. ISSN 0804-4643.