Template:Comparison of early clinical experience with antiestrogens for advanced breast cancer

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Comparison of early clinical experience with antiestrogens for advanced breast cancer

Antiestrogen Dosage Year(s) Response rate Toxicity
Template:No selflink 500–4,500 mg/day 1960 25% Acute psychotic episodes
Template:No selflink 100–300 mg/day 1964–1974 34% Fears of cataracts
Template:No selflink 180–240 mg/day 1976 31% Cataracts, ichthyosis, photophobia
Template:No selflink 20–40 mg/day 1971–1973 31% Transient thrombocytopeniaa
Footnotes: a = "The particular advantage of this drug is the low incidence of troublesome side effects (25)." "Side effects were usually trivial (26)." Sources: [1][2]
Template documentation

References

  1. Jensen EV, Jordan VC (June 2003). "The estrogen receptor: a model for molecular medicine". Clin. Cancer Res. 9 (6): 1980–9. PMID 12796359.
  2. Howell, Anthony; Jordan, V. Craig (2013). "Adjuvant Antihormone Therapy". In Craig, Jordan V. (ed.). Estrogen Action, Selective Estrogen Receptor Modulators And Women's Health: Progress And Promise. World Scientific. pp. 229–254. doi:10.1142/9781848169586_0010. ISBN 978-1-84816-959-3.