Template:Major side effects of bicalutamide alone

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Major side effects of Template:No selflink[1][2][3][4][5][6][7]

Frequency Class of effect Effect
Very common (≥10%) Reproductive system and breast disorders  Breast tenderness[lower-alpha 1]
 Gynecomastia[lower-alpha 1]
Common (1-10%) General and psychiatric disorders  Asthenia
 Decreased libido
 Erectile dysfunction
 Hot flashes
Skin and subcutaneous
tissue disorders
 Decreased body hair
Hepato-biliary disorders  Elevated liver enzymes[lower-alpha 2]
Uncommon (0.1-1%) Immune system disorders and hypersensitivity reactions  Angioedema
 Hives
Rare (<0.1%) or unknown Respiratory disorders  Lung disease[lower-alpha 3]
Skin and subcutaneous tissue disorders  Sensitivity to light
Hepato-biliary disorders  Liver toxicity[lower-alpha 3]
Template:Noteslist
Template documentation

References

  1. Mcleod DG (September 2002). "Emerging role of adjuvant hormonal therapy". Urology. 60 (3 Suppl 1): 13–20, discussion 21. doi:10.1016/S0090-4295(02)01562-5. PMID 12231039.
  2. https://pdf.hres.ca/dpd_pm/00009096.PDF
  3. Bennett CL, Raisch DW, Sartor O (October 2002). "Pneumonitis associated with nonsteroidal antiandrogens: presumptive evidence of a class effect". Annals of Internal Medicine. 137 (7): 625. doi:10.7326/0003-4819-137-7-200210010-00029. PMID 12353966. An estimated 0.77% of the 6,480 nilutamide-treated patients, 0.04% of the 41,700 flutamide-treated patients, and 0.01% of the 86,800 bicalutamide-treated patients developed pneumonitis during the study period.
  4. Molina Mancero, Guillermo; Picón, Xavier; Di Tullio, Fernando; Ernst, Glenda; Dezanzo, Pablo; Salvado, Alejandro; Chertcoff, Julio F (2016). "Neumonía intersticial inducida por bloqueo androgénico máximo como tratamiento de cáncer de próstata avanzado" [Fatal interstitial lung disease associated with maximum androgen blockade. Report of one case]. Revista médica de Chile. 144 (10): 1356–1359. doi:10.4067/S0034-98872016001000017. ISSN 0034-9887.
  5. Lee K, Oda Y, Sakaguchi M, Yamamoto A, Nishigori C (May 2016). "Drug-induced photosensitivity to bicalutamide - case report and review of the literature". Photodermatol Photoimmunol Photomed. 32 (3): 161–4. doi:10.1111/phpp.12230. PMID 26663090.
  6. Gretarsdottir, Helga M.; Bjornsdottir, Elin; Bjornsson, Einar S. (2018). "Bicalutamide-Associated Acute Liver Injury and Migratory Arthralgia: A Rare but Clinically Important Adverse Effect". Case Reports in Gastroenterology. 12 (2): 266–270. doi:10.1159/000485175. ISSN 1662-0631.
  7. Anderson J (March 2003). "The role of antiandrogen monotherapy in the treatment of prostate cancer". BJU Int. 91 (5): 455–61. doi:10.1046/j.1464-410X.2003.04026.x. PMID 12603397. S2CID 8639102.


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