Template:Major side effects of bicalutamide alone
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| Frequency | Class of effect | Effect |
|---|---|---|
| Very common (≥10%) | Reproductive system and breast disorders | • Breast tenderness[lower-alpha 1] • Gynecomastia[lower-alpha 1] |
| Common (1-10%) | General and psychiatric disorders | • Asthenia • Decreased libido • Erectile dysfunction • Hot flashes |
| Skin and subcutaneous tissue disorders |
• Decreased body hair | |
| Hepato-biliary disorders | • Elevated liver enzymes[lower-alpha 2] | |
| Uncommon (0.1-1%) | Immune system disorders and hypersensitivity reactions | • Angioedema • Hives |
| Rare (<0.1%) or unknown | Respiratory disorders | • Lung disease[lower-alpha 3] |
| Skin and subcutaneous tissue disorders | • Sensitivity to light | |
| Hepato-biliary disorders | • Liver toxicity[lower-alpha 3] | |
| Template:Noteslist | ||
References
- ↑ Mcleod DG (September 2002). "Emerging role of adjuvant hormonal therapy". Urology. 60 (3 Suppl 1): 13–20, discussion 21. doi:10.1016/S0090-4295(02)01562-5. PMID 12231039.
- ↑ https://pdf.hres.ca/dpd_pm/00009096.PDF
- ↑ Bennett CL, Raisch DW, Sartor O (October 2002). "Pneumonitis associated with nonsteroidal antiandrogens: presumptive evidence of a class effect". Annals of Internal Medicine. 137 (7): 625. doi:10.7326/0003-4819-137-7-200210010-00029. PMID 12353966.
An estimated 0.77% of the 6,480 nilutamide-treated patients, 0.04% of the 41,700 flutamide-treated patients, and 0.01% of the 86,800 bicalutamide-treated patients developed pneumonitis during the study period.
- ↑ Molina Mancero, Guillermo; Picón, Xavier; Di Tullio, Fernando; Ernst, Glenda; Dezanzo, Pablo; Salvado, Alejandro; Chertcoff, Julio F (2016). "Neumonía intersticial inducida por bloqueo androgénico máximo como tratamiento de cáncer de próstata avanzado" [Fatal interstitial lung disease associated with maximum androgen blockade. Report of one case]. Revista médica de Chile. 144 (10): 1356–1359. doi:10.4067/S0034-98872016001000017. ISSN 0034-9887.
- ↑ Lee K, Oda Y, Sakaguchi M, Yamamoto A, Nishigori C (May 2016). "Drug-induced photosensitivity to bicalutamide - case report and review of the literature". Photodermatol Photoimmunol Photomed. 32 (3): 161–4. doi:10.1111/phpp.12230. PMID 26663090.
- ↑ Gretarsdottir, Helga M.; Bjornsdottir, Elin; Bjornsson, Einar S. (2018). "Bicalutamide-Associated Acute Liver Injury and Migratory Arthralgia: A Rare but Clinically Important Adverse Effect". Case Reports in Gastroenterology. 12 (2): 266–270. doi:10.1159/000485175. ISSN 1662-0631.
- ↑ Anderson J (March 2003). "The role of antiandrogen monotherapy in the treatment of prostate cancer". BJU Int. 91 (5): 455–61. doi:10.1046/j.1464-410X.2003.04026.x. PMID 12603397. S2CID 8639102.
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